Development of the peptidergic modulation of a rhythmic pattern generating network.

The stomatogastric ganglion (STG) of adult lobsters and crabs receives dense aminergic and peptidergic projections. The neuropeptides are found in sensory neurons and in descending interneurons that modulate the output of the rhythmic central pattern generating networks in the STG. We describe the presence of these peptidergic projections in the adult Homarus americanus, and the effects of some of these neuropeptides on the motor patterns of the adult STG. We describe the developmental acquisition of these neuropeptides during embryonic and larval times and demonstrate that the immature STG networks are already sensitive to a variety of neuromodulators.