| Literature DB >> 10612594 |
B R Henke1, K K Adkison, S G Blanchard, L M Leesnitzer, R A Mook, K D Plunket, J A Ray, C Roberson, R Unwalla, T M Willson.
Abstract
The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. These new analogs are selective for PPARgamma vs the other PPAR subtypes, and the most potent compounds in this series are comparable to in vitro potencies at PPARgamma reported for the thiazolidinedione-based antidiabetic drugs currently in clinical use.Entities:
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Year: 1999 PMID： 10612594 DOI： 10.1016/s0960-894x(99)00603-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823