Literature DB >> 10612592

Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.

J Ishida1, H K Wang, K F Bastow, C Q Hu, K H Lee.   

Abstract

Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Alpha-(4-nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 microg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).

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Year:  1999        PMID： 10612592     DOI： 10.1016/s0960-894x(99)00598-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells.

Authors:  Lei Zhang; Fan Zhang; Wenjun Zhang; Lu Chen; Neng Gao; Yulong Men; Xiaojun Xu; Ying Jiang
Journal:  Cancer Biol Ther       Date:  2015-09-18       Impact factor: 4.742

2.  Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation.

Authors:  Kunal Kumar; Peng Wang; Roberto Sanchez; Ethan A Swartz; Andrew F Stewart; Robert J DeVita
Journal:  J Med Chem       Date:  2018-08-21       Impact factor: 7.446

3.  Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.

Authors:  Xinran Geng; Yichang Ren; Fangfang Wang; Danmei Tian; Xinsheng Yao; Youwei Zhang; Jinshan Tang
Journal:  Biochem Biophys Res Commun       Date:  2018-03-01       Impact factor: 3.575

4.  Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Authors:  Rachid Skouta; Miki Hayano; Kenichi Shimada; Brent R Stockwell
Journal:  Bioorg Med Chem Lett       Date:  2012-06-30       Impact factor: 2.823

5.  A series of beta-carboline derivatives inhibit the kinase activity of PLKs.

Authors:  Xiaomin Han; Jing Zhang; Liang Guo; Rihui Cao; Yongzhen Li; Ni Li; Qin Ma; Jialin Wu; Yanchang Wang; Shuyi Si
Journal:  PLoS One       Date:  2012-10-03       Impact factor: 3.240

6.  JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21.

Authors:  Xinyi Yang; Wei Wang; Jiang-Jiang Qin; Ming-Hai Wang; Horrick Sharma; John K Buolamwini; Hui Wang; Ruiwen Zhang
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240

7.  Anti-tumor Activity of N [(E)-1-(2-hydroxyphenyl) Methylidene], N-[(E)-2-Phenylethylidene], N [(E,2E)-3-Phenyl-2-propenylidene], and N [(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines.

Authors:  F Shabani; S Ghammamy; A Jahazi; F Siavoshifar
Journal:  J Young Pharm       Date:  2010-10

8.  Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies.

Authors:  Michael Tarpley; Helen O Oladapo; Dillon Strepay; Thomas B Caligan; Lhoucine Chdid; Hassan Shehata; Jose R Roques; Rhashad Thomas; Christopher P Laudeman; Rob U Onyenwoke; David B Darr; Kevin P Williams
Journal:  Eur J Pharm Sci       Date:  2021-03-27       Impact factor: 5.112

9.  A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.

Authors:  Zachary A Yochum; Jessica Cades; Lucia Mazzacurati; Neil M Neumann; Susheel K Khetarpal; Suman Chatterjee; Hailun Wang; Myriam A Attar; Eric H-B Huang; Sarah N Chatley; Katriana Nugent; Ashwin Somasundaram; Johnathan A Engh; Andrew J Ewald; Yoon-Jae Cho; Charles M Rudin; Phuoc T Tran; Timothy F Burns
Journal:  Mol Cancer Res       Date:  2017-08-29       Impact factor: 5.852

10.  Antitumor activity of 6-(cyclohexylamino)-1, 3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) complexes on K562 and Jurkat cell lines.

Authors:  Fahmideh Shabani; Shahriar Ghammamy; Khayroallah Mehrani; Mohammad Bagher Teimouri; Masoud Soleimani; Saeid Kaviani
Journal:  Bioinorg Chem Appl       Date:  2009-01-26       Impact factor: 7.778
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