| Literature DB >> 10612589 |
C J Dinsmore1, T M Williams, T J O'Neill, D Liu, E Rands, J C Culberson, R B Lobell, K S Koblan, N E Kohl, J B Gibbs, A I Oliff, S L Graham, G D Hartman.
Abstract
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically improved potency and gave highly cell active compounds.Entities:
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Year: 1999 PMID： 10612589 DOI： 10.1016/s0960-894x(99)00605-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823