| Literature DB >> 10612588 |
Y C Chia1, K S Chen, Y L Chang, C M Teng, Y C Wu.
Abstract
Seventeen aporphines were tested for antiplatelet activity. L-(+)-hemovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5'-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 microM against AA-induced platelet aggregation.Entities:
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Year: 1999 PMID： 10612588 DOI： 10.1016/s0960-894x(99)00593-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823