BACKGROUND: There is a critical number of bacteria above which tissue responds with infection. This balance of 10(5) or fewer bacteria/g tissue is also required for wound healing to proceed normally. This study evaluated whether a chronic wound once in bacterial balance can maintain that balance over time. METHODS: Serial biopsies for bacterial analyses were obtained weekly during a blinded, placebo-controlled cytokine clinical trial of pressure ulcers. To enter the trial ulcers had to be debrided and have a bacterial count of 10(5) or fewer bacteria/g tissue with no beta-hemolytic streptococci. RESULTS: In all, 96% of cultures (350/363) remained at <10(2) bacteria/g tissue over the 5-week trial; 3% had 10(2) to 10(5), and only 1% had >10(5) bacteria/g tissue. CONCLUSION:Chronic pressure ulcers, once debrided and brought into bacterial balance, will remain in bacterial balance if cared for and kept free of necrotic tissue.
RCT Entities:
BACKGROUND: There is a critical number of bacteria above which tissue responds with infection. This balance of 10(5) or fewer bacteria/g tissue is also required for wound healing to proceed normally. This study evaluated whether a chronic wound once in bacterial balance can maintain that balance over time. METHODS: Serial biopsies for bacterial analyses were obtained weekly during a blinded, placebo-controlled cytokine clinical trial of pressure ulcers. To enter the trial ulcers had to be debrided and have a bacterial count of 10(5) or fewer bacteria/g tissue with no beta-hemolytic streptococci. RESULTS: In all, 96% of cultures (350/363) remained at <10(2) bacteria/g tissue over the 5-week trial; 3% had 10(2) to 10(5), and only 1% had >10(5) bacteria/g tissue. CONCLUSION: Chronic pressure ulcers, once debrided and brought into bacterial balance, will remain in bacterial balance if cared for and kept free of necrotic tissue.
Authors: Samuel J Hooper; Steven L Percival; Katja E Hill; David W Thomas; A J Hayes; David W Williams Journal: Int Wound J Date: 2012-03-08 Impact factor: 3.315
Authors: Hannah Trøstrup; Christian J Lerche; Lars J Christophersen; Kim Thomsen; Peter Ø Jensen; Hans Petter Hougen; Niels Høiby; Claus Moser Journal: Int Wound J Date: 2017-11-27 Impact factor: 3.315
Authors: F Jacobsen; C Fisahn; M Sorkin; I Thiele; T Hirsch; I Stricker; T Klaassen; A Roemer; B Fugmann; L Steinstraesser Journal: Antimicrob Agents Chemother Date: 2011-02-22 Impact factor: 5.191
Authors: Charlotte E Davies; Katja E Hill; Melanie J Wilson; Phil Stephens; C Michael Hill; Keith G Harding; David W Thomas Journal: J Clin Microbiol Date: 2004-08 Impact factor: 5.948
Authors: Lars Steinstraesser; M Sorkin; A D Niederbichler; M Becerikli; J Stupka; A Daigeler; M R Kesting; I Stricker; F Jacobsen; M Schulte Journal: Arch Dermatol Res Date: 2009-12-03 Impact factor: 3.017