| Literature DB >> 10612006 |
C Amornrut1, T Toida, T Imanari, E R Woo, H Park, R Linhardt, S J Wu, Y S Kim.
Abstract
A new polysaccharide composed of galactan sulfate with a beta-(1-->3)-glycosidic linkage has been isolated from the marine clam species Meretrix petechialis. The polysaccharide was homogeneous in its composition containing D-galactose. The glycosidic linkage was examined by 2D DQF-COSY and 2D NOESY spectroscopy. The coupling constant of anomeric proton was 7.8 Hz, suggesting a beta-galacto configuration. The downfield shift of H-2 of galactose residue demonstrated the presence of 2-O-sulfonate group. TQF-COSY confirmed that the C-6 position was substituted with a sulfonate group. The anti-HIV activity of the polysaccharides has been evaluated by the inhibition of syncytia formation. The fusion index and percentage fusion inhibition of sulfated galactan were 0.34 and 56% at 200 micrograms/mL.Entities:
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Year: 1999 PMID： 10612006 DOI： 10.1016/s0008-6215(99)00188-3
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104