Literature DB >> 106120

Synthesis of steroidal nitrosoureas with antitumor activity.

H Y Lam, A Begleiter, G J Goldenberg, C M Wong.   

Abstract

Four steroidal nitrosoureas with structures which may permit specific binding to estrogen receptor were synthesized. Inhibitory activity was observed against the growth of the DMBA-induced transplantable rat mammary tumor 13762.

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Year:  1979        PMID： 106120     DOI： 10.1021/jm00188a015

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Synthesis and antineoplastic activity of CNC-cysteamine and related compounds.

Authors:  W C Tang; J Schmid; H H Fiebig; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  Probing the human estrogen receptor-α binding requirements for phenolic mono- and di-hydroxyl compounds: a combined synthesis, binding and docking study.

Authors:  Christopher McCullough; Terrence S Neumann; Jayapal Reddy Gone; Zhengjie He; Christian Herrild; Julie Wondergem Nee Lukesh; Rajesh K Pandey; William A Donaldson; Daniel S Sem
Journal:  Bioorg Med Chem       Date:  2013-11-21       Impact factor: 3.641

3.  Cytotoxic esters of 1,1-bis-(4-hydroxyphenyl)-2-phenyl-but-1-ene with selective antitumor activity against estrogen receptor-containing mammary tumors.

Authors:  M L Schuderer; M R Schneider
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

4.  Cytostatic activity of steroid linked nitrosoureas.

Authors:  W J Zeller; J Schreiber; A D Ho; D Schmähl; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

5.  Evaluation of new estrogen-linked 2-chloroethylnitrosoureas. I. Short term anticancer efficacy in methylnitrosourea-induced rat mammary carcinoma and hormonal activity in mice.

Authors:  M R Berger; J Floride; J Schreiber; D Schmähl; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

6.  Nitrosourea and nitrosocarbamate derivatives of the antiestrogen tamoxifen as potential estrogen receptor-mediated cytotoxic agents in human breast cancer cells.

Authors:  L L Wei; B S Katzenellenbogen; D W Robertson; D M Simpson; J A Katzenellenbogen
Journal:  Breast Cancer Res Treat       Date:  1986       Impact factor: 4.872
  6 in total

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