Literature DB >> 10611325

Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.

J Y Kwon1, J M Park, B S Gim, S J Han, J Lee, Y J Kim.   

Abstract

Mediator proteins are required for transcriptional regulation of most genes in yeast. Mammalian Mediator homologs also function as transcriptional coactivators in vitro; however, their physiological role in gene-specific transcription is not yet known. To determine the role of Mediator proteins in the development of complex organisms, we purified putative Mediator complexes from Caenorhabditis elegans and analyzed their phenotypes in vivo. C. elegans Mediator homologs were assembled into two multiprotein complexes. RNA interference assays showed that the CeMed6, CeMed7, and CeMed10/CeNut2 gene products are required for the expression of developmentally regulated genes, but are dispensable for expression of the ubiquitously expressed genes tested in this study. Therefore, the gene-specific function of Mediator as an integrator of transcriptional regulatory signals is evolutionarily conserved and is essential for C. elegans development.

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Year:  1999        PMID： 10611325      PMCID： PMC24760          DOI： 10.1073/pnas.96.26.14990

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

Authors:  W Gu; S Malik; M Ito; C X Yuan; J D Fondell; X Zhang; E Martinez; J Qin; R G Roeder
Journal:  Mol Cell       Date:  1999-01       Impact factor: 17.970

Review 2.  An engine for nucleosome remodeling.

Authors:  A Travers
Journal:  Cell       Date:  1999-02-05       Impact factor: 41.582

3.  Global transcription regulators of eukaryotes.

Authors:  S Björklund; G Almouzni; I Davidson; K P Nightingale; K Weiss
Journal:  Cell       Date:  1999-03-19       Impact factor: 41.582

4.  Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation.

Authors:  S J Han; Y C Lee; B S Gim; G H Ryu; S J Park; W S Lane; Y J Kim
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

5.  The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.

Authors:  S Ryu; S Zhou; A G Ladurner; R Tjian
Journal:  Nature       Date:  1999-02-04       Impact factor: 49.962

6.  An activator binding module of yeast RNA polymerase II holoenzyme.

Authors:  Y C Lee; J M Park; S Min; S J Han; Y J Kim
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

7.  Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID.

Authors:  J D Fondell; M Guermah; S Malik; R G Roeder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

8.  Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

Authors:  C Rachez; B D Lemon; Z Suldan; V Bromleigh; M Gamble; A M Näär; H Erdjument-Bromage; P Tempst; L P Freedman
Journal:  Nature       Date:  1999-04-29       Impact factor: 49.962

9.  Composite co-activator ARC mediates chromatin-directed transcriptional activation.

Authors:  A M Näär; P A Beaurang; S Zhou; S Abraham; W Solomon; R Tjian
Journal:  Nature       Date:  1999-04-29       Impact factor: 49.962

10.  Mediator protein mutations that selectively abolish activated transcription.

Authors:  L C Myers; C M Gustafsson; K C Hayashibara; P O Brown; R D Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205
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  19 in total

1.  Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification.

Authors:  M Boube; C Faucher; L Joulia; D L Cribbs; H M Bourbon
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

2.  Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes.

Authors:  B S Gim; J M Park; J H Yoon; C Kang; Y J Kim
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

3.  Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development.

Authors:  Ana Terriente-Félix; Ana López-Varea; Jose F de Celis
Journal:  Genetics       Date:  2010-03-16       Impact factor: 4.562

4.  A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene.

Authors:  H Zhang; S W Emmons
Journal:  Genes Dev       Date:  2000-09-01       Impact factor: 11.361

5.  Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.

Authors:  H Spåhr; C O Samuelsen; V Baraznenok; I Ernest; D Huylebroeck; J E Remacle; T Samuelsson; T Kieselbach; S Holmberg; C M Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

6.  The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress.

Authors:  Saloni Mathur; Shailendra Vyas; Sanjay Kapoor; Akhilesh Kumar Tyagi
Journal:  Plant Physiol       Date:  2011-10-21       Impact factor: 8.340

7.  Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation.

Authors:  David Adler; Hamidur Rahaman; Pernilla Wittung-Stafshede; Stefan Björklund
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-23       Impact factor: 11.205

8.  Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors.

Authors:  Shwu-Yuan Wu; Tianyuan Zhou; Cheng-Ming Chiang
Journal:  Mol Cell Biol       Date:  2003-09       Impact factor: 4.272

9.  Evolution of disorder in Mediator complex and its functional relevance.

Authors:  Malini Nagulapalli; Sourobh Maji; Nidhi Dwivedi; Pradeep Dahiya; Jitendra K Thakur
Journal:  Nucleic Acids Res       Date:  2015-11-20       Impact factor: 16.971

10.  Overexpression of OsMed16 Inhibits the Growth of Rice and Causes Spontaneous Cell Death.

Authors:  Jie Jiang; Guangzhe Yang; Yafeng Xin; Zhigang Wang; Wei Yan; Zhufeng Chen; Xiaoyan Tang; Jixing Xia
Journal:  Genes (Basel)       Date:  2021-04-27       Impact factor: 4.096
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