Literature DB >> 1061110

Prevention of viral-chemical co-carcinogenesis in vitro by type-specific anti-viral antibody.

P J Price, T M Bellew, M P King, A E Freeman, R V Gilden, R J Huebner.   

Abstract

Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody specific for the leukemia virus prior to and during treatment with methylcholanthrene. Sister cultures were not protected by neutralizing antibody specific for the B-tropic radiation leukemia virus. This demonstrates clearly a definite type specific role for Rauscher murine leukemia virus in the 2-methylcholanthrene transformation system in rat cells.

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Year:  1976        PMID： 1061110      PMCID： PMC335858          DOI： 10.1073/pnas.73.1.152

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  7 in total

1.  Morphological transformation of rat embryo cells induced by diethylnitrosamine and murine leukemia viruses.

Authors:  A E Freeman; P J Price; H J Igel; J C Young; J M Maryak; R J Huebner
Journal:  J Natl Cancer Inst       Date:  1970-01       Impact factor: 13.506

2.  RNA tumor virus genomes as determinants of chemically-induced transformation in vitro.

Authors:  A E Freeman; P J Price; E M Zimmerman; G J Kelloff; R J Huebner
Journal:  Bibl Haematol       Date:  1973

3.  Streptonigrin inhibition of 3-methylcholanthrene transformation in vitro.

Authors:  P J Price; W A Suk; G J Spahn; M A Chirigos; J A Lane; R J Huebner
Journal:  Proc Soc Exp Biol Med       Date:  1974-04

4.  Assay of C-type virus infectivity by measurement of RNA-dependent DNA polymerase activity.

Authors:  G J Kelloff; M Hatanaka; R V Gilden
Journal:  Virology       Date:  1972-04       Impact factor: 3.616

5.  Type C RNA tumor viruses as determinants of chemical carcinogenesis: effects of sequence of treatment.

Authors:  P J Price; W A Suk; A E Freeman
Journal:  Science       Date:  1972-09-15       Impact factor: 47.728

6.  5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells.

Authors:  A E Freeman; R V Gilden; M L Vernon; R G Wolford; P E Hugunin; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

7.  Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice.

Authors:  M LIEBERMAN; H S KAPLAN
Journal:  Science       Date:  1959-08-14       Impact factor: 47.728
  7 in total
  6 in total

1.  Role of antibodies to murine leukemia virus p15E transmembrane protein in immunotherapy against AKR leukemia: a model for studies in human acquired immunodeficiency syndrome.

Authors:  H J Thiel; H Schwarz; P Fischinger; D Bolognesi; W Schäfer
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

2.  Chemical carcinogen-mouse mammary tumor virus interactions in cell transformation.

Authors:  D K Howard; J Schlom; P B Fisher
Journal:  In Vitro       Date:  1983-01

3.  Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus.

Authors:  R Waters; N Mishra; N Bouck; G DiMayorca; J D Regan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

4.  Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes.

Authors:  R J Huebner; R V Gilden; R Toni; R W Hill; R W Trimmer; D C Fish; B Sass
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

5.  The co-carcinogenic activity of 4-nitropyridine-1-oxide (4-NPO) and prevention of transformation by type-specific anti-viral antibodies.

Authors:  P J Price; A E Auletta; M P King; P M Hugunin; R J Huebner
Journal:  In Vitro       Date:  1976-08

6.  Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum.

Authors:  P J Price; W A Suk; R L Peters; R V Gilden; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205
  6 in total

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