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Literature DB >> 10609158

PET measurement of the coronary flow reserve and microcirculatory function.

Abstract

This review article discusses some of the potentially beneficial effects of calcium antagonists on the coronary microcirculation. These include their vasodilating action on coronary resistance vessels as well as their effects on extravascular resistance (i.e. intramyocardial pressure). Examples are presented of how the non-invasive measurement of myocardial blood flow and flow reserve by means of positron emission tomography (PET) can contribute to the understanding of the effects of drug treatment on the coronary microcirculation. The action of calcium antagonists on the coronary microcirculation can contribute to explain the efficacy of these drugs against ischemia and ischemia-reperfusion damage.

Entities: Chemical

Mesh：

Substances：
Calcium Channel Blockers

Year: 1999 PMID： 10609158 DOI： 10.1007/BF03044223

Source DB: PubMed Journal: Herz ISSN： 0340-9937 Impact factor: 1.740

74 in total

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Authors: B J Maron; S E Epstein; W C Roberts
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PET measurement of the coronary flow reserve and microcirculatory function.

1. Mechanism of the effect of coronary artery stenosis on coronary flow in the dog.

2. Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine.

3. In vivo observation of subendocardial microvessels of the beating porcine heart using a needle-probe videomicroscope with a CCD camera.

4. Prognostic value of angiographic indices of coronary artery disease from the Coronary Artery Surgery Study (CASS).

5. Coronary flow during exercise after selective alpha 1- and alpha 2-adrenergic blockade.

6. Regional myocardial blood flow in awake dogs.

7. Relation between myocardial blood flow and the severity of coronary-artery stenosis.

8. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries.

9. Phasic blood flow velocity pattern in epimyocardial microvessels in the beating canine left ventricle.

10. Sudden death in young athletes.

Review 1. Spontaneous and iatrogenic microembolization. A new concept for the pathogenesis of coronary artery disease.

Review 2. Beta-blockers and coronary flow reserve: the importance of a vasodilatory action.