| Literature DB >> 10608786 |
C Buxton Bridges1, J M Katz, W H Seto, P K Chan, D Tsang, W Ho, K H Mak, W Lim, J S Tam, M Clarke, S G Williams, A W Mounts, J S Bresee, L A Conn, T Rowe, J Hu-Primmer, R A Abernathy, X Lu, N J Cox, K Fukuda.
Abstract
The first outbreak of avian influenza A (H5N1) occurred among humans in Hong Kong in 1997. To estimate the risk of person-to-person transmission, a retrospective cohort study was conducted to compare the prevalence of H5N1 antibody among health care workers (HCWs) exposed to H5N1 case-patients with the prevalence among nonexposed HCWs. Information on H5N1 case-patient and poultry exposures and blood samples for H5N1-specific antibody testing were collected. Eight (3.7%) of 217 exposed and 2 (0.7%) of 309 nonexposed HCWs were H5N1 seropositive (P=.01). The difference remained significant after controlling for poultry exposure (P=.01). This study presents the first epidemiologic evidence that H5N1 viruses were transmitted from patients to HCWs. Human-to-human transmission of avian influenza may increase the chances for the emergence of a novel influenza virus with pandemic potential.Entities:
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Year: 2000 PMID： 10608786 DOI： 10.1086/315213
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226