| Literature DB >> 10608774 |
I N Okeke1, A Lamikanra, J Czeczulin, F Dubovsky, J B Kaper, J P Nataro.
Abstract
Enteroaggregative Escherichia coli (EAEC) has been implicated in acute and persistent diarrhea, and most strains harbor a member of a partially-conserved plasmid family (called pAA). We studied EAEC isolated from Nigerian children aged <5 years to elucidate the roles of plasmid and chromosomal EAEC loci. We tested a total of 131 EAEC strains isolated from acute diarrhea case patients and control subjects for hybridization with 8 pAA plasmid-derived and 2 chromosomal gene probes, for several in vitro phenotypes and for resistance to antimicrobial agents. Using by multiple logistic regression, we found genes encoding the AAF/II fimbriae to be strongly associated with diarrhea in this population. EAEC strains appear to be of heterogeneous virulence, and data suggest that AAF/II may be a marker for pathogenic strains.Entities:
Mesh：
Year: 2000 PMID： 10608774 DOI： 10.1086/315204
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226