| Literature DB >> 10608761 |
R T Schooley1, J Mladenovic, A Sevin, S Chiu, S A Miles, R J Pomerantz, T B Campbell, D Bell, D Ambruso, R Wong, A Landay, R W Coombs, L Fox, M Kamoun, J Jacovini.
Abstract
Granulocyte colony-stimulating factor (r-met Hu G-CSF; filgrastim; 10 microgram/kg/day for 7 days) was used to mobilize CD34+stem cells into the peripheral blood of human immunodeficiency virus type 1 (HIV-1)-infected individuals and a group of HIV-1-uninfected donors as a measure of immunologic reserve in HIV-1-infected people. G-CSF mobilized CD34+ cells of HIV-1-infected individuals with cell counts >500 CD4+ cells/mm3, as well as in HIV-1-uninfected donors. In contrast, CD34 cell mobilization was significantly blunted in HIV-1-infected individuals with cell counts <500 CD4+ cells/mm3 (<200 cell days vs. >650 cell days, P<.0005, compared with the >500 CD4+ cell cohort). At least 1.75x10(7) CD34 cells were harvested by leukapheresis from patients in each study cohort. CD34+ cell viability and the ability to differentiate precursor cells into myeloid and erythroid progenitor cells were not affected by HIV-1 infection.Entities:
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Year: 2000 PMID： 10608761 DOI： 10.1086/315168
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226