Literature DB >> 10608287

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

R J Siarey1, E J Carlson, C J Epstein, A Balbo, S I Rapoport, Z Galdzicki.   

Abstract

Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus.

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Year:  1999        PMID： 10608287     DOI： 10.1016/s0028-3908(99)00083-0

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  68 in total

1.  2001 William Allan Award Address. From Down syndrome to the "human" in "human genetics".

Authors:  Charles J Epstein
Journal:  Am J Hum Genet       Date:  2001-12-26       Impact factor: 11.025

2.  Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn.

Authors:  Samuel Hernández-González; Raúl Ballestín; Rosa López-Hidalgo; Javier Gilabert-Juan; José Miguel Blasco-Ibáñez; Carlos Crespo; Juan Nácher; Emilio Varea
Journal:  Neurochem Res       Date:  2014-11-16       Impact factor: 3.996

3.  Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice.

Authors:  Ayelet Cooper; Gayane Grigoryan; Liora Guy-David; Michael M Tsoory; Alon Chen; Eitan Reuveny
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

4.  Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome.

Authors:  Ananya Mitra; Martina Blank; Daniel V Madison
Journal:  Brain Res       Date:  2012-01-03       Impact factor: 3.252

5.  Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome.

Authors:  Chie Harashima; David M Jacobowitz; Jassir Witta; Rosemary C Borke; Tyler K Best; Richard J Siarey; Zygmunt Galdzicki
Journal:  J Comp Neurol       Date:  2006-02-10       Impact factor: 3.215

6.  Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats.

Authors:  Thomas C Foster; Ashok Kumar
Journal:  Neurobiol Learn Mem       Date:  2007-02-05       Impact factor: 2.877

7.  Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome.

Authors:  Verónica Vidal; Susana García-Cerro; Paula Martínez; Andrea Corrales; Sara Lantigua; Rebeca Vidal; Noemí Rueda; Laurence Ozmen; Maria-Clemencia Hernández; Carmen Martínez-Cué
Journal:  Mol Neurobiol       Date:  2017-07-17       Impact factor: 5.590

8.  The Down syndrome critical region regulates retinogeniculate refinement.

Authors:  Martina Blank; Peter G Fuerst; Beth Stevens; Navid Nouri; Lowry Kirkby; Deepti Warrier; Ben A Barres; Marla B Feller; Andrew D Huberman; Robert W Burgess; Craig C Garner
Journal:  J Neurosci       Date:  2011-04-13       Impact factor: 6.167

Review 9.  Prospects for improving brain function in individuals with Down syndrome.

Authors:  Alberto C S Costa; Jonah J Scott-McKean
Journal:  CNS Drugs       Date:  2013-09       Impact factor: 5.749

10.  CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.

Authors:  Melissa J Alldred; Helen M Chao; Sang Han Lee; Judah Beilin; Brian E Powers; Eva Petkova; Barbara J Strupp; Stephen D Ginsberg
Journal:  Hippocampus       Date:  2018-02-12       Impact factor: 3.899
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