Literature DB >> 10607889

[3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue.

N S Kula1, R J Baldessarini, F I Tarazi, R Fisser, S Wang, J Trometer, J L Neumeyer.   

Abstract

[3H]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane (beta-CIT) was prepared and evaluated. With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. Affinity and selectivity for 53 compounds assayed with [3H]beta-CIT and standard DAT radioligand [3H]GBR-12935 were highly correlated (r0.95). [3H]beta-CIT is proposed as a useful, high-affinity DAT radioprobe.

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Year:  1999        PMID： 10607889     DOI： 10.1016/s0014-2999(99)00695-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  In vivo voltammetric monitoring of norepinephrine release in the rat ventral bed nucleus of the stria terminalis and anteroventral thalamic nucleus.

Authors:  Jinwoo Park; Brian M Kile; R Mark Wightman
Journal:  Eur J Neurosci       Date:  2009-11-25       Impact factor: 3.386

2.  Synthesis, radiolabeling and baboon SPECT imaging of 2beta-carbomethoxy-3beta-(3'-[(123)I]iodophenyl)tropane ([(123)I]YP256) as a serotonin transporter radiotracer.

Authors:  Frederic Bois; Ronald M Baldwin; Louis Amici; Mohammed S Al-Tikriti; Nora Kula; Ross Baldessarini; Robert B Innis; Julie K Staley; Gilles D Tamagnan
Journal:  Nucl Med Biol       Date:  2008-01       Impact factor: 2.408

3.  Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.

Authors:  Marisa B Rosenberg; F Ivy Carroll; S Stevens Negus
Journal:  J Pain       Date:  2013-01-16       Impact factor: 5.820

4.  The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents.

Authors:  John A Gruner; Val R Marcy; Yin-Guo Lin; Donna Bozyczko-Coyne; Michael J Marino; Maciej Gasior
Journal:  Sleep       Date:  2009-11       Impact factor: 5.849

5.  The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior.

Authors:  Gor Sarkisyan; Amanda J Roberts; Peter B Hedlund
Journal:  Behav Brain Res       Date:  2010-01-25       Impact factor: 3.332

Review 6.  Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs.

Authors:  Jan Booij; Paul Kemp
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-10-30       Impact factor: 9.236

7.  The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density.

Authors:  Sidney H VanNess; Michael J Owens; Clinton D Kilts
Journal:  BMC Genet       Date:  2005-11-27       Impact factor: 2.797
  7 in total

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