Literature DB >> 10606761

Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases.

M V Gamble1, N L Mata, A T Tsin, J R Mertz, W S Blaner.   

Abstract

Recent studies of the human, mouse and bovine genes for 11-cis-retinol dehydrogenase (11cRDH) and human and mouse 9-cis-retinol dehydrogenase (9cRDH) suggest that they are homologs of the same enzyme. This conclusion is inconsistent with earlier literature indicating that 11cRDH is expressed solely in the eye and does not utilize 9-cis-retinol as a substrate. We have compared directly the kinetic properties of recombinant human and mouse 9cRDH with those of bovine 11cRDH for 9-cis- and 11-cis-retinol and investigated the inhibitory properties of 13-cis-retinoic acid on each of these enzymes. Human and mouse 9cRDH and bovine 11cRDH have very similar kinetic properties towards 9-cis- and 11-cis-retinol oxidation and they respond identically to 13-cis-retinoic acid inhibition. Our biochemical data are consistent with the conclusion that 9cRDH and 11cRDH are the same enzyme.

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Year:  2000        PMID： 10606761     DOI： 10.1016/s0167-4838(99)00232-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  13 in total

1.  Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

Authors:  So Ra Kim; Nathan Fishkin; Jian Kong; Koji Nakanishi; Rando Allikmets; Janet R Sparrow
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-26       Impact factor: 11.205

2.  Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

Authors:  T Michael Redmond; Eugenia Poliakov; Shirley Yu; Jen-Yue Tsai; Zhongjian Lu; Susan Gentleman
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-06       Impact factor: 11.205

3.  Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.

Authors:  Marcin Golczak; Akiko Maeda; Grzegorz Bereta; Tadao Maeda; Philip D Kiser; Silke Hunzelmann; Johannes von Lintig; William S Blaner; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2008-01-14       Impact factor: 5.157

4.  Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Authors:  Roxana A Radu; Nathan L Mata; Steven Nusinowitz; Xinran Liu; Paul A Sieving; Gabriel H Travis
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-01       Impact factor: 11.205

5.  Stereoisomeric specificity of the retinoid cycle in the vertebrate retina.

Authors:  G F Jang; J K McBee; A M Alekseev; F Haeseleer; K Palczewski
Journal:  J Biol Chem       Date:  2000-09-08       Impact factor: 5.157

Review 6.  Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.

Authors:  Gabriel H Travis; Marcin Golczak; Alexander R Moise; Krzysztof Palczewski
Journal:  Annu Rev Pharmacol Toxicol       Date:  2007       Impact factor: 13.820

7.  Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle.

Authors:  Alberto Muñiz; Whitney A Greene; Mark L Plamper; Jae Hyek Choi; Anthony J Johnson; Andrew T Tsin; Heuy-Ching Wang
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-01-09       Impact factor: 4.799

8.  Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

Authors:  Bernat Crosas; David J Hyndman; Oriol Gallego; Sílvia Martras; Xavier Parés; T Geoffrey Flynn; Jaume Farrés
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

9.  Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.

Authors:  Roxana A Radu; Quan Yuan; Jane Hu; Jennifer H Peng; Marcia Lloyd; Steven Nusinowitz; Dean Bok; Gabriel H Travis
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-05-30       Impact factor: 4.799

Review 10.  A novel cone visual cycle in the cone-dominated retina.

Authors:  Albert Muniz; Elia T Villazana-Espinoza; Andrea L Hatch; Simon G Trevino; Donald M Allen; Andrew T C Tsin
Journal:  Exp Eye Res       Date:  2007-05-24       Impact factor: 3.467
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