Literature DB >> 1060612

High coumarin 7-hydroxylase activity does not protect mice against Warfarin.

I E Lush, C J Arnold.   

Abstract

Sixteen strains of mice varied widely in their ability to 7-hydroxylate injected coumarin to form umbelliferone, which is excreted in the urine. The same strains also varied in their resistance to the lethal effects of dietary Warfarin. There was no correlation between hydroxylating ability and Warfarin resistance.

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Year:  1975        PMID： 1060612     DOI： 10.1038/hdy.1975.92

Source DB:  PubMed          Journal:  Heredity (Edinb)        ISSN： 0018-067X            Impact factor:   3.821


  3 in total

1.  Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro.

Authors:  P Honkakoski; P Arvela; R Juvonen; M A Lang; M Kairaluoma; O Pelkonen
Journal:  Br J Clin Pharmacol       Date:  1992-03       Impact factor: 4.335

2.  Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases.

Authors:  P Pellinen; F Stenbäck; A Rautio; O Pelkonen; M Lang; M Pasanen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-10       Impact factor: 3.000

3.  A major gene controlling warfarin-resistance in the house mouse.

Authors:  M E Wallace; F J MacSwiney
Journal:  J Hyg (Lond)       Date:  1976-04
  3 in total

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