Literature DB >> 10602675

The potential use of heat-shock proteins to vaccinate against mycobacterial infections.

C L Silva1.   

Abstract

Over the last few years, some of our experiments in which mycobacterial heat-shock protein (HSP) antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that the mycobacterial HSP65 antigen can confer protection equal to that from live BCG vaccine in mice.

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Year:  1999        PMID: 10602675     DOI: 10.1016/s1286-4579(99)80046-x

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  5 in total

1.  Stable extracellular RNA fragments of Mycobacterium tuberculosis induce early apoptosis in human monocytes via a caspase-8 dependent mechanism.

Authors:  Andrés Obregón-Henao; María A Duque-Correa; Mauricio Rojas; Luis F García; Patrick J Brennan; Blanca L Ortiz; John T Belisle
Journal:  PLoS One       Date:  2012-01-09       Impact factor: 3.240

2.  Transcriptional profiling of Mycobacterium tuberculosis replicating ex vivo in blood from HIV- and HIV+ subjects.

Authors:  Michelle B Ryndak; Krishna K Singh; Zhengyu Peng; Susan Zolla-Pazner; Hualin Li; Lu Meng; Suman Laal
Journal:  PLoS One       Date:  2014-04-22       Impact factor: 3.240

3.  Rv2299c, a novel dendritic cell-activating antigen of Mycobacterium tuberculosis, fused-ESAT-6 subunit vaccine confers improved and durable protection against the hypervirulent strain HN878 in mice.

Authors:  Han-Gyu Choi; Seunga Choi; Yong Woo Back; Seungwha Paik; Hye-Soo Park; Woo Sik Kim; Hongmin Kim; Seung Bin Cha; Chul Hee Choi; Sung Jae Shin; Hwa-Jung Kim
Journal:  Oncotarget       Date:  2017-03-21

4.  Heterologous expression of Brucella abortus GroEL heat-shock protein in Lactococcus lactis.

Authors:  Anderson Miyoshi; Luis G Bermúdez-Humarán; Luciana A Ribeiro; Yves Le Loir; Sérgio C Oliveira; Philippe Langella; Vasco Azevedo
Journal:  Microb Cell Fact       Date:  2006-03-23       Impact factor: 5.328

5.  Mycobacterium tuberculosis GrpE, A Heat-Shock Stress Responsive Chaperone, Promotes Th1-Biased T Cell Immune Response via TLR4-Mediated Activation of Dendritic Cells.

Authors:  Woo Sik Kim; In Duk Jung; Jong-Seok Kim; Hong Min Kim; Kee Woong Kwon; Yeong-Min Park; Sung Jae Shin
Journal:  Front Cell Infect Microbiol       Date:  2018-03-27       Impact factor: 5.293

  5 in total

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