Literature DB >> 10602210

Chemically Modified Antisense Oligonucleotides-Recent Improvements of RNA Binding and Ribonuclease H Recruitment.

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Abstract

The incorporation of rationally designed sugar or nucleobase modifications into oligonucleotides gives remarkable improvements of the antisense activity. For example, the cytosine analogue 1 recognizes both the Watson-Crick and the Hoogsteen site of a guanine nucleotide 2, which dramatically enhances the RNA-binding affinity and selectivity.

Entities:  

Year:  1999        PMID： 10602210     DOI： 10.1002/(sici)1521-3773(19991203)38:23<3466::aid-anie3466>3.3.co;2-o

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

1.  2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies.

Authors:  C J Wilds; M J Damha
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

2.  A novel dual lock method for down-regulation of genes, in which a target mRNA is captured at 2 independent positions by linked locked nucleic acid antisense oligonucleotides.

Authors:  Ryohei Takata; Gouki Makado; Ayaka Kitamura; Hajime Watanabe; Tadashi Wada
Journal:  RNA Biol       Date:  2016-02-18       Impact factor: 4.652

3.  Flexible non-nucleotide linkers as loop replacements in short double helical RNAs.

Authors:  W Pils; R Micura
Journal:  Nucleic Acids Res       Date:  2000-05-01       Impact factor: 16.971

Review 4.  Towards Personalized Allele-Specific Antisense Oligonucleotide Therapies for Toxic Gain-of-Function Neurodegenerative Diseases.

Authors:  Jacob Helm; Ludger Schöls; Stefan Hauser
Journal:  Pharmaceutics       Date:  2022-08-16       Impact factor: 6.525
  4 in total

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