| Literature DB >> 10601559 |
S Sarkar1, N R Jana, J Yonemoto, C Tohyama, H Sone.
Abstract
A human carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver tumors in female rats. In this study, we examined the effects of estrogen on an arylhydrocarbon receptor (AhR)-responsible protein, CYP1A1 expression induced by TCDD in female rat livers. The induction of CYP1A1 by a dose of 300 ng TCDD/kg and its resultant enzymatic activity were significantly enhanced by 5 microg 17beta-estradiol/kg body weight treatment to both intact and ovariectomized rats. Immunoblot analysis showed a increase in nuclear AhR due to estrogen, TCDD or both, suggesting that estrogen is involved in the activation of CYP1A1 gene after the formation of AhR-TCDD complex.Entities:
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Year: 2000 PMID： 10601559 DOI： 10.3892/ijo.16.1.141
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650