BACKGROUND & AIMS: Nutritional depletion is frequently present in patients with chronic obstructive pulmonary disease, but it is unknown whether a difference exists between the two subtypes. The aim of this study was to determine whether patterns of tissue depletion were different between emphysema and chronic bronchitis patients and whether these were related to pulmonary function. METHODS: In 99 severe COPD patients and 28 healthy volunteers, body weight and composition were assessed by dual-energy X-ray absorptiometry. Patients were stratified into chronic bronchitis (n=50) and emphysema (n=49) by high-resolution computed tomography. RESULTS: Lean mass depletion was found in 37% of the emphysema patients and in 12% of the chronic bronchitis patients. The emphysema patients had lower values for body mass index than the other groups (P< 0.01), mainly due to a lower lean mass (P< 0.01) and bone mineral content (P< 0.01). Fat mass was also lower in the emphysema group compared to the chronic bronchitis group (P< 0.001). The chronic bronchitis patients had a higher fat mass (P< 0.05) and a lower bone mineral content (P< 0.01) than the healthy volunteers. CONCLUSIONS: Substantial differences in body composition were found not only between chronic obstructive pulmonary disease patients and healthy volunteers, but also between chronic bronchitis and emphysema patients.
BACKGROUND & AIMS: Nutritional depletion is frequently present in patients with chronic obstructive pulmonary disease, but it is unknown whether a difference exists between the two subtypes. The aim of this study was to determine whether patterns of tissue depletion were different between emphysema and chronic bronchitispatients and whether these were related to pulmonary function. METHODS: In 99 severe COPDpatients and 28 healthy volunteers, body weight and composition were assessed by dual-energy X-ray absorptiometry. Patients were stratified into chronic bronchitis (n=50) and emphysema (n=49) by high-resolution computed tomography. RESULTS: Lean mass depletion was found in 37% of the emphysemapatients and in 12% of the chronic bronchitispatients. The emphysemapatients had lower values for body mass index than the other groups (P< 0.01), mainly due to a lower lean mass (P< 0.01) and bone mineral content (P< 0.01). Fat mass was also lower in the emphysema group compared to the chronic bronchitis group (P< 0.001). The chronic bronchitispatients had a higher fat mass (P< 0.05) and a lower bone mineral content (P< 0.01) than the healthy volunteers. CONCLUSIONS: Substantial differences in body composition were found not only between chronic obstructive pulmonary diseasepatients and healthy volunteers, but also between chronic bronchitis and emphysemapatients.
Authors: François Maltais; Marc Decramer; Richard Casaburi; Esther Barreiro; Yan Burelle; Richard Debigaré; P N Richard Dekhuijzen; Frits Franssen; Ghislaine Gayan-Ramirez; Joaquim Gea; Harry R Gosker; Rik Gosselink; Maurice Hayot; Sabah N A Hussain; Wim Janssens; Micheal I Polkey; Josep Roca; Didier Saey; Annemie M W J Schols; Martijn A Spruit; Michael Steiner; Tanja Taivassalo; Thierry Troosters; Ioannis Vogiatzis; Peter D Wagner Journal: Am J Respir Crit Care Med Date: 2014-05-01 Impact factor: 21.405
Authors: Takao Tsuji; Neil J Kelly; Saeko Takahashi; Adriana S Leme; A McGarry Houghton; Steven D Shapiro Journal: Am J Respir Cell Mol Biol Date: 2014-12 Impact factor: 6.914
Authors: Merry-Lynn N McDonald; Alejandro A Diaz; Erica Rutten; Sharon M Lutz; Rola Harmouche; Raul San Jose Estepar; Greg Kinney; John E Hokanson; Barbara A Gower; Emiel F M Wouters; Stephen I Rennard; Craig P Hersh; Richard Casaburi; Mark T Dransfield; Edwin K Silverman; George R Washko Journal: Eur Respir J Date: 2017-12-14 Impact factor: 16.671
Authors: Renate Jonker; Nicolaas E P Deutz; Gerdien C Ligthart-Melis; Anthony J Zachria; Eugene A Veley; Rajesh Harrykissoon; Mariëlle P K J Engelen Journal: Clin Nutr Date: 2018-07-31 Impact factor: 7.324