| Literature DB >> 10600742 |
R S Lanciotti1, J T Roehrig, V Deubel, J Smith, M Parker, K Steele, B Crise, K E Volpe, M B Crabtree, J H Scherret, R A Hall, J S MacKenzie, C B Cropp, B Panigrahy, E Ostlund, B Schmitt, M Malkinson, C Banet, J Weissman, N Komar, H M Savage, W Stone, T McNamara, D J Gubler.
Abstract
In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus species) as well as the deaths of several exotic birds at a zoological park in the same area. Complete genome sequencing of a flavivirus isolated from the brain of a dead Chilean flamingo (Phoenicopterus chilensis), together with partial sequence analysis of envelope glycoprotein (E-glycoprotein) genes amplified from several other species including mosquitoes and two fatal human cases, revealed that West Nile (WN) virus circulated in natural transmission cycles and was responsible for the human disease. Antigenic mapping with E-glycoprotein-specific monoclonal antibodies and E-glycoprotein phylogenetic analysis confirmed these viruses as WN. This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998.Entities:
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Year: 1999 PMID： 10600742 DOI： 10.1126/science.286.5448.2333
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728