Literature DB >> 10599860

Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine.

P Fagergren1, Y L Hurd.   

Abstract

The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups. Following binge cocaine injections (3 x 15 mg/kg), elevated levels were found in the central amygdala of male but not female rats. In the medial accumbens shell CART mRNA was elevated after cocaine, but only in the non-treated females. The present results support a role of mesolimbic CART in psychostimulant drug action.

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Year:  1999        PMID： 10599860     DOI： 10.1097/00001756-199911080-00034

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  25 in total

1.  Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter.

Authors:  George A Rogge; Li-Ling Shen; Michael J Kuhar
Journal:  Brain Res       Date:  2010-05-06       Impact factor: 3.252

2.  Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection.

Authors:  Yun Xu; Wenri Zhang; Judith Klaus; Jennifer Young; Ines Koerner; Laird C Sheldahl; Patricia D Hurn; Francisco Martínez-Murillo; Nabil J Alkayed
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-13       Impact factor: 11.205

Review 3.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

4.  Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences.

Authors:  Martin O Job; Joanna Perry; Li L Shen; Michael J Kuhar
Journal:  Neuropeptides       Date:  2014-01-10       Impact factor: 3.286

Review 5.  Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets.

Authors:  Michael J Kuhar; Jason N Jaworski; George W Hubert; Kelly B Philpot; Geraldina Dominguez
Journal:  AAPS J       Date:  2005-09-02       Impact factor: 4.009

6.  The effects of infusions of CART 55-102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats.

Authors:  David J Rademacher; Elyse M Sullivan; David A Figge
Journal:  Psychopharmacology (Berl)       Date:  2009-12-16       Impact factor: 4.530

7.  Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis.

Authors:  Jason N Jaworski; Heather L Kimmel; Darlene A Mitrano; Ronald J Tallarida; Michael J Kuhar
Journal:  Neuropeptides       Date:  2007-02-07       Impact factor: 3.286

8.  Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence.

Authors:  Falk W Lohoff; Paul J Bloch; Andrew E Weller; Aleksandra H Nall; Glenn A Doyle; Russell J Buono; Thomas N Ferraro; Kyle M Kampman; Helen M Pettinati; Charles A Dackis; David W Oslin; Charles P O'Brien; Wade H Berrettini
Journal:  Neurosci Lett       Date:  2008-05-24       Impact factor: 3.046

Review 9.  CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system.

Authors:  George W Hubert; Douglas C Jones; Mark C Moffett; George Rogge; Michael J Kuhar
Journal:  Biochem Pharmacol       Date:  2007-07-26       Impact factor: 5.858

10.  Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration.

Authors:  Willard M Freeman; Kruti M Patel; Robert M Brucklacher; Malinda E Lull; Mandi Erwin; Drake Morgan; David C S Roberts; Kent E Vrana
Journal:  Neuropsychopharmacology       Date:  2007-09-12       Impact factor: 7.853
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