Literature DB >> 10599848

Immunohistochemical localization of CDK5 activator p39 in the rat brain.

Y Honjyo1, Y Kawamoto, S Nakamura, S Nakano, I Akiguchi.   

Abstract

We examined the immunohistochemical localization of p39, the regulatory subunit of cyclin-dependent kinase 5 (Cdk5), in the adult rat brain. Cdk5 requires either p39 or p35 to assume its active form in the mammalian CNS. We developed a specific antibody against p39, and localized p39-immunoreactivity in the rat brain. p39-immunoreactivity was observed in the neuronal somata of the cerebral cortex, hippocampus and basal ganglia, and also in the Purkinje cells. Immunopositive astrocytes and oligodendrocytes were scattered throughout the rat brain. p35 immunoactivity has been observed exclusively in neurons and was never detected in glial cells. The present results suggest that p39 and p35 may have different functional roles in the regulation of Cdk5 in the rat CNS.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10599848     DOI： 10.1097/00001756-199911080-00022

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.

Authors:  Gregory N Ruegsegger; Ryan G Toedebusch; Thomas E Childs; Kolter B Grigsby; Frank W Booth
Journal:  J Physiol       Date:  2016-09-15       Impact factor: 5.182

2.  Neuronal cyclin-dependent kinase 5 activity is critical for survival.

Authors:  T Tanaka; T Ohshima; P Rajan; N D Amin; A Cho; T Sreenath; H C Pant; R O Brady; A B Kulkarni
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

3.  p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.

Authors:  Andrew N Bankston; Wenqi Li; Hui Zhang; Li Ku; Guanglu Liu; Filomena Papa; Lixia Zhao; James A Bibb; Franca Cambi; Seema K Tiwari-Woodruff; Yue Feng
Journal:  J Biol Chem       Date:  2013-05-03       Impact factor: 5.157

4.  Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5.

Authors:  David Petrik; Sanghee Yun; Sarah E Latchney; Sohail Kamrudin; Junie A LeBlanc; James A Bibb; Amelia J Eisch
Journal:  PLoS One       Date:  2013-08-26       Impact factor: 3.240

5.  CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes.

Authors:  A Rai; S Tripathi; R Kushwaha; P Singh; P Srivastava; S Sanyal; S Bandyopadhyay
Journal:  Cell Death Dis       Date:  2014-01-30       Impact factor: 8.469

6.  Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.

Authors:  Sashi Kesavapany; Kwok-Fai Lau; Steven Ackerley; Steven J Banner; Stephen J A Shemilt; Jonathan D Cooper; P Nigel Leigh; Christopher E Shaw; Declan M McLoughlin; Christopher C J Miller
Journal:  J Neurosci       Date:  2003-06-15       Impact factor: 6.167

7.  Proteomic identification of proteins suggestive of immune-mediated response or neuronal degeneration in serum of achalasia patients.

Authors:  Seon Kyo Im; Mari Yeo; Kwang Jae Lee
Journal:  Gut Liver       Date:  2013-06-11       Impact factor: 4.519
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.