Literature DB >> 10597528

A method for meta-analysis of genome searches: application to simulated data.

L H Wise1, C M Lewis.   

Abstract

Genome searches have been performed for many complex traits, and in some cases several searches have been performed in a single disease. Replication of significant results is rare, and a systematic method of reviewing results from a number of searches is needed. A method for meta-analysis is presented which provides a systematic descriptive overview of the separate analyses while dealing with some of the problems specific to meta-analysis of genome searches. The results of two separate meta-analyses correctly indicate the presence of susceptibility loci on chromosomes 1, 3, and 5 in the GAW11 Problem 2 data.

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Substances：

Year:  1999        PMID： 10597528     DOI： 10.1002/gepi.13701707126

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  5 in total

1.  Genomewide scans of complex human diseases: true linkage is hard to find.

Authors:  J Altmüller; L J Palmer; G Fischer; H Scherb; M Wjst
Journal:  Am J Hum Genet       Date:  2001-09-14       Impact factor: 11.025

2.  Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.

Authors:  Amalia Martinez-Mir; Abraham Zlotogorski; Derek Gordon; Lynn Petukhova; Jianhong Mo; T Conrad Gilliam; Douglas Londono; Chad Haynes; Jurg Ott; Maria Hordinsky; Krassimira Nanova; David Norris; Vera Price; Madeleine Duvic; Angela M Christiano
Journal:  Am J Hum Genet       Date:  2007-01-05       Impact factor: 11.025

3.  Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.

Authors:  Abraham M Brown; Derek Gordon; Hsinhwa Lee; Fabienne Wavrant-De Vrièze; Elena Cellini; Silvia Bagnoli; Benedetta Nacmias; Sandro Sorbi; John Hardy; John P Blass
Journal:  Neurochem Res       Date:  2007-03-07       Impact factor: 3.996

4.  Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease.

Authors:  Albert Rosenberger; Manu Sharma; Bertram Müller-Myhsok; Thomas Gasser; Heike Bickeböller
Journal:  BMC Genet       Date:  2007-07-02       Impact factor: 2.797

5.  Genome-Wide Linkage Study Meta-Analysis of Male Sexual Orientation.

Authors:  Alan R Sanders; Gary W Beecham; Shengru Guo; Judith A Badner; Sven Bocklandt; Brian S Mustanski; Dean H Hamer; Eden R Martin
Journal:  Arch Sex Behav       Date:  2021-06-02
  5 in total

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