Literature DB >> 10597465

The importance of watching our weights: how the choice of weights for non-independent sib pairs can dramatically alter results.

P Van Eerdewegh1, J Dupuis, S L Santangelo, L B Hayward, D Blacker.   

Abstract

Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.

Mesh：

Year:  1999        PMID： 10597465     DOI： 10.1002/gepi.1370170763

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  3 in total

1.  Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs.

Authors:  J Dupuis; P Van Eerdewegh
Journal:  Am J Hum Genet       Date:  2000-06-26       Impact factor: 11.025

2.  Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings.

Authors:  Ming-Huei Chen; Paul Van Eerdewegh; Quentin B Vincent; Alexandre Alcais; Laurent Abel; Josée Dupuis
Journal:  Hum Hered       Date:  2009-12-04       Impact factor: 0.444

3.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.

Authors:  J T Williams; H Begleiter; B Porjesz; H J Edenberg; T Foroud; T Reich; A Goate; P Van Eerdewegh; L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025
  3 in total

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