Literature DB >> 10597459

Whole genome association studies for genes affecting alcohol dependence.

F Sun1, R Cheng, W D Flanders, Q Yang, M J Khoury.   

Abstract

We applied the transmission/disequilibrium test (TDT) for sibs (S-TDT) and for families with one parent (1-TDT), to the Collaborative Study on the Genetics of Alcoholism data set. The combined test is used to screen the whole genome to locate genes responsible for alcohol dependence. This analysis supports the previous finding that the region close to GABRB1 on chromosome 4 might be associated with alcohol dependence. The regions close to D6S474 and D11S1998 are also of particular interest. We found segregation distortion at the GR1K1 locus. The segregation distortion might be due to the binning method used in genotyping at this locus.

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Year:  1999        PMID： 10597459     DOI： 10.1002/gepi.1370170757

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  6 in total

1.  A genome wide search for alcoholism susceptibility genes.

Authors:  Shirley Y Hill; Sa Shen; Nicholas Zezza; Eric K Hoffman; Mark Perlin; William Allan
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2004-07-01       Impact factor: 3.568

2.  Whole-genome linkage analysis in mapping alcoholism genes using single-nucleotide polymorphisms and microsatellites.

Authors:  Shuang Wang; Song Huang; Nianjun Liu; Liang Chen; Cheongeun Oh; Hongyu Zhao
Journal:  BMC Genet       Date:  2005-12-30       Impact factor: 2.797

3.  GABRB1 Single Nucleotide Polymorphism Associated with Altered Brain Responses (but not Performance) during Measures of Impulsivity and Reward Sensitivity in Human Adolescents.

Authors:  Theodora Duka; Kyriaki Nikolaou; Sarah L King; Tobias Banaschewski; Arun L W Bokde; Christian Büchel; Fabiana M Carvalho; Patricia J Conrod; Herta Flor; Jürgen Gallinat; Hugh Garavan; Andreas Heinz; Tianye Jia; Penny Gowland; Jean-Luc Martinot; Tomáš Paus; Marcella Rietschel; Trevor W Robbins; Michael Smolka; Gunter Schumann; David N Stephens
Journal:  Front Behav Neurosci       Date:  2017-02-15       Impact factor: 3.558

4.  Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.

Authors:  H Le-Niculescu; N J Case; L Hulvershorn; S D Patel; D Bowker; J Gupta; R Bell; H J Edenberg; M T Tsuang; R Kuczenski; M A Geyer; Z A Rodd; A B Niculescu
Journal:  Transl Psychiatry       Date:  2011-04-26       Impact factor: 6.222

5.  Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons.

Authors:  Zhuting Li; Meaghan Cogswell; Kathryn Hixson; Amy R Brooks-Kayal; Shelley J Russek
Journal:  Front Mol Neurosci       Date:  2018-08-21       Impact factor: 5.639

6.  Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

Authors:  Quentin M Anstee; Susanne Knapp; Edward P Maguire; Alastair M Hosie; Philip Thomas; Martin Mortensen; Rohan Bhome; Alonso Martinez; Sophie E Walker; Claire I Dixon; Kush Ruparelia; Sara Montagnese; Yu-Ting Kuo; Amy Herlihy; Jimmy D Bell; Iain Robinson; Irene Guerrini; Andrew McQuillin; Elizabeth M C Fisher; Mark A Ungless; Hugh M D Gurling; Marsha Y Morgan; Steve D M Brown; David N Stephens; Delia Belelli; Jeremy J Lambert; Trevor G Smart; Howard C Thomas
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  6 in total

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