Literature DB >> 10596892

Megalin in normal tissues and carcinoma cells carries oligo/poly alpha2,8 deaminoneuraminic acid as a unique posttranslational modification.

M Ziak1, M Meier, J Roth.   

Abstract

In rat kidney, megalin, a member of the low density lipoprotein receptor gene family, is the sole glycoprotein which carries oligo/poly alpha2,8 deaminoneuraminic acid (KDN) as a posttranslational modification. We have investigated immunoprecipitated megalin from rat brain, lung and placenta, mouse yolk sac carcinoma and megalin synthesizing carcinoma cell lines, for presence of this unique glycan structure. Our immunoblot analysis revealed the presence of oligo/poly alpha2,8 KDN on megalin in all the studied normal tissues and carcinoma cells. Furthermore, it is demonstrated to be part of oligosaccharides O-glycosidically linked to megalin.

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Year:  1999        PMID： 10596892     DOI： 10.1023/a:1007068102436

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  19 in total

1.  Identification of megalin as the sole rat kidney sialoglycoprotein containing poly alpha2,8 deaminoneuraminic acid.

Authors:  M Ziak; D Kerjaschki; M G Farquhar; J Roth
Journal:  J Am Soc Nephrol       Date:  1999-02       Impact factor: 10.121

2.  Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein.

Authors:  W Poller; T E Willnow; J Hilpert; J Herz
Journal:  J Biol Chem       Date:  1995-02-10       Impact factor: 5.157

3.  Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells.

Authors:  M Lundstrom; R A Orlando; M S Saedi; L Woodward; H Kurihara; M G Farquhar
Journal:  Am J Pathol       Date:  1993-11       Impact factor: 4.307

4.  Fluorometric high-performance liquid chromatography of N-acetyl- and N-glycolylneuraminic acids and its application to their microdetermination in human and animal sera, glycoproteins, and glycolipids.

Authors:  S Hara; Y Takemori; M Yamaguchi; M Nakamura; Y Ohkura
Journal:  Anal Biochem       Date:  1987-07       Impact factor: 3.365

5.  Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.

Authors:  A Saito; S Pietromonaco; A K Loo; M G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

6.  Monoclonal antibody specific for alpha 2-->8-linked oligo deaminated neuraminic acid (KDN) sequences in glycoproteins. Preparation and characterization of a monoclonal antibody and its application in immunohistochemistry.

Authors:  A Kanamori; S Inoue; Z Xulei; C Zuber; J Roth; K Kitajima; J Ye; F A Troy; Y Inoue
Journal:  Histochemistry       Date:  1994-06

7.  Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).

Authors:  G Zheng; D R Bachinsky; I Stamenkovic; D K Strickland; D Brown; G Andres; R T McCluskey
Journal:  J Histochem Cytochem       Date:  1994-04       Impact factor: 2.479

8.  Occurrence of poly(alpha2,8-deaminoneuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoproteins.

Authors:  M Ziak; B Qu; X Zuo; C Zuber; A Kanamori; K Kitajima; S Inoue; Y Inoue; J Roth
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-02       Impact factor: 11.205

9.  gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex.

Authors:  S Stefansson; M Z Kounnas; J Henkin; R K Mallampalli; D A Chappell; D K Strickland; W S Argraves
Journal:  J Cell Sci       Date:  1995-06       Impact factor: 5.285

10.  The expression of megalin (gp330) and LRP diverges during F9 cell differentiation.

Authors:  R P Czekay; R A Orlando; L Woodward; E D Adamson; M G Farquhar
Journal:  J Cell Sci       Date:  1995-04       Impact factor: 5.285
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  5 in total

1.  Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis.

Authors:  Kunio Kawanishi; Sudeshna Saha; Sandra Diaz; Michael Vaill; Aniruddha Sasmal; Shoib S Siddiqui; Biswa Choudhury; Kumar Sharma; Xi Chen; Ian C Schoenhofen; Chihiro Sato; Ken Kitajima; Hudson H Freeze; Anja Münster-Kühnel; Ajit Varki
Journal:  J Clin Invest       Date:  2021-03-01       Impact factor: 14.808

Review 2.  KDN (deaminated neuraminic acid): dreamful past and exciting future of the newest member of the sialic acid family.

Authors:  Sadako Inoue; Ken Kitajima
Journal:  Glycoconj J       Date:  2006-07       Impact factor: 2.916

3.  Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media.

Authors:  Sadako Inoue; Geetha L Poongodi; Nimmagadda Suresh; Tschining Chang; Yasuo Inoue
Journal:  Glycoconj J       Date:  2006-07       Impact factor: 2.916

4.  Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.

Authors:  Mélanie Teintenier-Lelièvre; Sylvain Julien; Sylvie Juliant; Yann Guerardel; Martine Duonor-Cérutti; Philippe Delannoy; Anne Harduin-Lepers
Journal:  Biochem J       Date:  2005-12-15       Impact factor: 3.857

5.  Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids.

Authors:  Hai Yu; Jiansong Cheng; Li Ding; Zahra Khedri; Yi Chen; Sharlene Chin; Kam Lau; Vinod Kumar Tiwari; Xi Chen
Journal:  J Am Chem Soc       Date:  2009-12-30       Impact factor: 15.419
  5 in total

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