Literature DB >> 10596759

The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice.

P Giraldo1, E Giménez, L Montoliu.   

Abstract

Variegation and inherited somatic mosaicism has been observed in transgenic mice carrying yeast artificial chromosomes (YACs) in which a DNAse I hypersensitive site (HS) located -12 kb upstream of the mouse tyrosinase gene had been deleted. At present, we are generating new transgenic animals with minor deletions of the HS.

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Year:  1999        PMID： 10596759     DOI： 10.1016/s1050-3862(99)00023-6

Source DB:  PubMed          Journal:  Genet Anal


  5 in total

1.  Multiple effects of genetic background on variegated transgene expression in mice.

Authors:  Margaret L Opsahl; Margaret McClenaghan; Anthea Springbett; Sarah Reid; Richard Lathe; Alan Colman; C Bruce A Whitelaw
Journal:  Genetics       Date:  2002-03       Impact factor: 4.562

Review 2.  Size matters: use of YACs, BACs and PACs in transgenic animals.

Authors:  P Giraldo; L Montoliu
Journal:  Transgenic Res       Date:  2001-04       Impact factor: 2.788

3.  Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity.

Authors:  Patricia Giraldo; Antonio Martínez; Lucía Regales; Alfonso Lavado; Angel García-Díaz; Angel Alonso; Ana Busturia; Lluís Montoliu
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

4.  Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis.

Authors:  Davide Seruggia; Almudena Fernández; Marta Cantero; Pawel Pelczar; Lluis Montoliu
Journal:  Nucleic Acids Res       Date:  2015-04-20       Impact factor: 16.971

5.  Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression.

Authors:  Davide Seruggia; Almudena Fernández; Marta Cantero; Ana Fernández-Miñán; José Luis Gomez-Skarmeta; Pawel Pelczar; Lluis Montoliu
Journal:  Sci Rep       Date:  2020-09-23       Impact factor: 4.379
  5 in total

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