Literature DB >> 10596451

Vascular alpha 1D-adrenoceptors: are they related to hypertension?

R Villalobos-Molina1, M Ibarra.   

Abstract

Heterogeneity of vascular alpha 1-adrenoceptor subtypes has been revealed by pharmacological and molecular biology studies (i.e., alpha 1A-, alpha 1B-, and alpha 1D-adrenoceptors). The alpha 1D-adrenoceptor subtype is predominantly involved in the contraction of a variety of vessels and its role in the control of blood pressure has been suggested, a phenomenon probably related to aging. Recent advances in the use of young pre-hypertensive rats and adult spontaneously hypertensive rats with one kidney and Grollman-type renal hypertension suggest vascular alpha 1D-adrenoceptor involvement in the increased blood pressure. The possible role of alpha 1D-adrenoceptors in the genesis/maintenance of hypertension is discussed in this review.

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Year:  1999        PMID： 10596451     DOI： 10.1016/s0188-0128(99)00047-0

Source DB:  PubMed          Journal:  Arch Med Res        ISSN： 0188-4409            Impact factor:   2.235


  8 in total

1.  Inhibition of the alpha(1D)-adrenergic receptor gene by RNA interference (RNAi) in rat vascular smooth muscle cells and its effects on other adrenergic receptors.

Authors:  Bei Sun; Ekaterina Kintsurashvili; Deborah Ona; Ivana Ignjacev-Lazich; Irene Gavras; Haralambos Gavras
Journal:  Vascul Pharmacol       Date:  2007-01-23       Impact factor: 5.773

2.  Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.

Authors:  C Ekaterina Rodríguez-Pérez; M Teresa Romero-Avila; Guadalupe Reyes-Cruz; J Adolfo García-Sáinz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-05-21       Impact factor: 3.000

Review 3.  Updates in the function and regulation of α1 -adrenoceptors.

Authors:  Juliana Akinaga; J Adolfo García-Sáinz; André S Pupo
Journal:  Br J Pharmacol       Date:  2019-04-01       Impact factor: 8.739

4.  Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes.

Authors:  L Methven; P C Simpson; J C McGrath
Journal:  Br J Pharmacol       Date:  2009-12       Impact factor: 8.739

5.  Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.

Authors:  Regina Gisbert; Khalid Ziani; Raquel Miquel; M Antonia Noguera; M Dolores Ivorra; Elsa Anselmi; Pilar D'Ocon
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

6.  Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II.

Authors:  R Villalobos-Molina; F G Vázquez-Cuevas; J J López-Guerrero; M C Figueroa-García; I A Gallardo-Ortiz; M Ibarra; M Rodríguez-Sosa; F J Gonzalez; G Elizondo
Journal:  Auton Autacoid Pharmacol       Date:  2008 Apr-Jul

7.  Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.

Authors:  Heather Irina Cohn; David M Harris; Stephanie Pesant; Michael Pfeiffer; Rui-Hai Zhou; Walter J Koch; Gerald W Dorn; Andrea D Eckhart
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-08-22       Impact factor: 4.733

Review 8.  Novel Structural Approaches to Study GPCR Regulation.

Authors:  Marco A Alfonzo-Méndez; Rocío Alcántara-Hernández; J Adolfo García-Sáinz
Journal:  Int J Mol Sci       Date:  2016-12-23       Impact factor: 5.923
  8 in total

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