OBJECTIVES: To study immune cell response and histocompability class II (HLA-DR) expression after aortic aneurysm repair. SETTING: University hospital, Sweden. SUBJECTS: 42 patients operated on for aortic aneurysm, 26 by an endovascular and 16 by an open technique. MAIN OUTCOME MEASURES: Analysis of HLA-DR expression and concentrations of blood mononuclear cells by flow cytometry. Splanchnic pH analysed by tonometry and interleukin-6 and tumour necrosis factor-alpha measured by enzyme-linked immunosorbent assay. RESULTS: The HLA-DR expression on lymphocytes did not change, whereas total HLA-DR expression on monocytes was downregulated, and more pronounced in five patients who developed severe postoperative complications. There were no differences in cell or HLA-DR responses between the two operations. CONCLUSIONS: Both endovascular and open repair of aortic aneurysm produced similar downregulation of monocyte HLA-DR expression and similar responses in circulating mononuclear blood cells. There was pronounced downregulation of monocyte HLA-DR expression in patients with severe postoperative complications.
OBJECTIVES: To study immune cell response and histocompability class II (HLA-DR) expression after aortic aneurysm repair. SETTING: University hospital, Sweden. SUBJECTS: 42 patients operated on for aortic aneurysm, 26 by an endovascular and 16 by an open technique. MAIN OUTCOME MEASURES: Analysis of HLA-DR expression and concentrations of blood mononuclear cells by flow cytometry. Splanchnic pH analysed by tonometry and interleukin-6 and tumour necrosis factor-alpha measured by enzyme-linked immunosorbent assay. RESULTS: The HLA-DR expression on lymphocytes did not change, whereas total HLA-DR expression on monocytes was downregulated, and more pronounced in five patients who developed severe postoperative complications. There were no differences in cell or HLA-DR responses between the two operations. CONCLUSIONS: Both endovascular and open repair of aortic aneurysm produced similar downregulation of monocyte HLA-DR expression and similar responses in circulating mononuclear blood cells. There was pronounced downregulation of monocyte HLA-DR expression in patients with severe postoperative complications.
Authors: Kerstin Kronholm Diab; Lennart Truedsson; Maria Albin; Jørn Nielsen Journal: Int Arch Occup Environ Health Date: 2008-12-02 Impact factor: 3.015