| Literature DB >> 10595365 |
J Hughes1, A Astriab, H Yoo, S Alahari, E Liang, D Sergueev, B R Shaw, R L Juliano.
Abstract
A variety of techniques are currently available to enhance the cellular uptake and pharmacological effectiveness of antisense oligonucleotides in the in vitro setting. The choice of technique will depend on the context of investigation, the likelihood of cytotoxity due to the delivery agents, and the ease and convenience of the approach. The considerations for the delivery of antisense molecules in the in vivo setting are likely to be quite different from the cell culture situation emphasized in this article.Entities:
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Year: 2000 PMID： 10595365 DOI： 10.1016/s0076-6879(00)13021-6
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600