| Literature DB >> 10595359 |
B R Shaw1, D Sergueev, K He, K Porter, J Summers, Z Sergueeva, V Rait.
Abstract
Nucleoside boranophosphates are distinctive in that one of the non-bridging oxygens in the phosphate diester 1 is replaced by a borane moiety (BH3). Although they retain the same net charge, BH3(-)-ODN have unique chemical and biochemical characteristics relative to other analogs. The change in polarity, lipophilicity, nuclease resistance, and the activation of RNase H cleavage of RNA in RNA: boranophosphate hybrids make boranophosphates very attractive for applications in enzymology and molecular biology and as potential antisense agents.Entities:
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Year: 2000 PMID： 10595359 DOI： 10.1016/s0076-6879(00)13015-0
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600