| Literature DB >> 1059163 |
S Daan, D Damassa, C S Pittendrigh, E R Smith.
Abstract
Castration of mice in freerunning conditions (total darkness, DD) causes a reduction of running wheel activity in the beginning of the active period (alpha) and stimulates activity at the end of alpha. Simultaneously, the period (tau) of the freerunning rhythm is increased. Both effects are abolished by implantation of a Silastic capsule from which a physiological dose of testosterone is released at a constant rate. The results are tentatively explained by differential endocrine influences on two oscillating components in the pacemaker of the circadian activity rhythm.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1059163 PMCID： PMC433074 DOI： 10.1073/pnas.72.9.3744
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205