Literature DB >> 10590285

Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp.

M Wainwright1, D A Phoenix, M Gaskell, B Marshall.   

Abstract

The toxicities and phototoxicities of methylene blue and its two methylated derivatives were measured against one standard and three vancomycin-resistant pathogenic strains of Enterococcus spp. Each of the compounds was bactericidal and the derivatives exhibited photobactericidal activity on illumination at a 'light' dose of 6.3 J/cm(2) against one or more of the strains. Increased bactericidal and photobactericidal activity in the methylated derivatives is thought to be due to their higher hydrophobicities allowing greater interaction with the bacterial cell wall. In addition, the derivatives exhibited higher inherent photosensitizing efficacies.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10590285     DOI： 10.1093/jac/44.6.823

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  18 in total

Review 1.  Clostridium difficile infection: molecular pathogenesis and novel therapeutics.

Authors:  Ardeshir Rineh; Michael J Kelso; Fatma Vatansever; George P Tegos; Michael R Hamblin
Journal:  Expert Rev Anti Infect Ther       Date:  2014-01       Impact factor: 5.091

2.  Antimicrobial photodynamic therapy in the colon: delivering a light punch to the guts?

Authors:  Mark Wainwright; Tianhong Dai; Michael R Hamblin
Journal:  Photochem Photobiol       Date:  2011-04-12       Impact factor: 3.421

3.  Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies.

Authors:  Xavier Ragàs; Tianhong Dai; George P Tegos; Montserrat Agut; Santi Nonell; Michael R Hamblin
Journal:  Lasers Surg Med       Date:  2010-07       Impact factor: 4.025

Review 4.  All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease.

Authors:  Tyler G St Denis; Tianhong Dai; Leonid Izikson; Christos Astrakas; Richard Rox Anderson; Michael R Hamblin; George P Tegos
Journal:  Virulence       Date:  2011-11-01       Impact factor: 5.882

Review 5.  Phototherapy and optical waveguides for the treatment of infection.

Authors:  Dingbowen Wang; Michelle Laurel Kuzma; Xinyu Tan; Tong-Chuan He; Cheng Dong; Zhiwen Liu; Jian Yang
Journal:  Adv Drug Deliv Rev       Date:  2021-11-03       Impact factor: 15.470

Review 6.  Thioridazine: resurrection as an antimicrobial agent?

Authors:  H K R Thanacoody
Journal:  Br J Clin Pharmacol       Date:  2007-08-31       Impact factor: 4.335

7.  The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms.

Authors:  C R Fontana; A D Abernethy; S Som; K Ruggiero; S Doucette; R C Marcantonio; C I Boussios; R Kent; J M Goodson; A C R Tanner; N S Soukos
Journal:  J Periodontal Res       Date:  2009-07-08       Impact factor: 4.419

8.  Potentiation of photoinactivation of Gram-positive and Gram-negative bacteria mediated by six phenothiazinium dyes by addition of azide ion.

Authors:  Kamola R Kasimova; Magesh Sadasivam; Giacomo Landi; Tadeusz Sarna; Michael R Hamblin
Journal:  Photochem Photobiol Sci       Date:  2014-11       Impact factor: 3.982

9.  Anti-staphylococcal activity and mode of action of thioridazine photoproducts.

Authors:  Tatiana Tozar; Sofia Santos Costa; Ana-Maria Udrea; Viorel Nastasa; Isabel Couto; Miguel Viveiros; Mihail Lucian Pascu; Mihaela Oana Romanitan
Journal:  Sci Rep       Date:  2020-10-22       Impact factor: 4.379

Review 10.  Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.

Authors:  Rui Yin; Tianhong Dai; Pinar Avci; Ana Elisa Serafim Jorge; Wanessa C M A de Melo; Daniela Vecchio; Ying-Ying Huang; Asheesh Gupta; Michael R Hamblin
Journal:  Curr Opin Pharmacol       Date:  2013-09-20       Impact factor: 5.547
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.