Literature DB >> 10588335

Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis.

U Wintergerst1, J D Gangemi, R J Whitley, S Chatterjee, E R Kern.   

Abstract

The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-alpha B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P = 0.021), whereas natural mouse interferon was inactive. Combination of acyclovir with Hu-IFN-alpha B/D had an additive effect.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10588335     DOI： 10.1016/s0166-3542(99)00055-8

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  4 in total

Review 1.  Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Clin Microbiol Rev       Date:  2020-02-12       Impact factor: 26.132

Review 2.  The role of Toll-like receptor signaling in human immunodeficiencies.

Authors:  Hanna Suhir; Amos Etzioni
Journal:  Clin Rev Allergy Immunol       Date:  2010-02       Impact factor: 8.667

Review 3.  Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System.

Authors:  Hina Singh; Jeffrey Koury; Marcus Kaul
Journal:  Viruses       Date:  2021-01-23       Impact factor: 5.048

Review 4.  Novel approaches and challenges to treatment of central nervous system viral infections.

Authors:  Avindra Nath; Kenneth L Tyler
Journal:  Ann Neurol       Date:  2013-09       Impact factor: 10.422
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.