| Literature DB >> 10587096 |
B Yu1, K Yamada, J P Gallagher.
Abstract
After uncoupling G-protein dependent post-synaptic GABA(B) receptors--without altering GABA(B) nerve terminal receptors--we demonstrate that the GABA(B) agonist, CGP44533, exhibits less efficacy and potency at GABA(B) auto- versus hetero-receptors. CGP44533 (1 and 10 microM) depressed monosynaptic GABA(A)-mediated transmission by 2 and 35%, but depressed glutamate mediated transmission by 41 and 78%, respectively. These data suggest a differential pharmacological sensitivity for CGP44533 at glutamate versus GABA releasing neurons.Entities:
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Year: 1999 PMID： 10587096 DOI： 10.1016/s0028-3908(99)00120-3
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250