| Literature DB >> 10586880 |
D W Burt1, C Bruley, I C Dunn, C T Jones, A Ramage, A S Law, D R Morrice, I R Paton, J Smith, D Windsor, A Sazanov, R Fries, D Waddington.
Abstract
Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years. On the basis of these rates we would expect 84 to 600 conserved segments in a chicken comparison with human or mouse. Here we build comparative maps between these species and estimate that numbers of conserved segments are in the lower part of this range. We conclude that the organization of the human genome is closer to that of the chicken than the mouse and by adding comparative mapping results from a range of vertebrates, we identify three possible phases of chromosome evolution. The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates.Entities:
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Year: 1999 PMID： 10586880 DOI： 10.1038/46555
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962