Literature DB >> 10586186

Congenital heart defects and maternal derangement of homocysteine metabolism.

L Kapusta1, M L Haagmans, E A Steegers, M H Cuypers, H J Blom, T K Eskes.   

Abstract

Methionine loading tests and folate, vitamin B(6), and vitamin B(12) analyses were performed in 27 mothers of children with congenital heart defects. Median fasting plasma homocysteine concentrations were significantly higher in the study group as compared with 56 control subjects (P =.0001). Maternal hyperhomocysteinemia may be a risk factor for congenital heart defects.

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Year:  1999        PMID： 10586186     DOI： 10.1016/s0022-3476(99)70102-2

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  32 in total

1.  Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.

Authors:  Norma A Balderrábano-Saucedo; Rocio Sánchez-Urbina; José A Sierra-Ramírez; Normand García-Hernández; Adriana Sánchez-Boiso; Miguel Klunder-Klunder; Diego Arenas-Aranda; Gabriela Bravo-Hernández; Penelope Noriega-Zapata; Alfredo Vizcaíno-Alarcón
Journal:  Pediatr Cardiol       Date:  2012-06-04       Impact factor: 1.655

Review 2.  Getting to the heart of the matter: epidemiology of cyanotic heart defects.

Authors:  Jennifer L Kornosky; Hamisu M Salihu
Journal:  Pediatr Cardiol       Date:  2008-01-10       Impact factor: 1.655

Review 3.  Impact of epigenetic dietary compounds on transgenerational prevention of human diseases.

Authors:  Yuanyuan Li; Sabita N Saldanha; Trygve O Tollefsbol
Journal:  AAPS J       Date:  2013-10-11       Impact factor: 4.009

4.  Associations between maternal genotypes and metabolites implicated in congenital heart defects.

Authors:  Shimul Chowdhury; Charlotte A Hobbs; Stewart L MacLeod; Mario A Cleves; Stepan Melnyk; S Jill James; Ping Hu; Stephen W Erickson
Journal:  Mol Genet Metab       Date:  2012-09-27       Impact factor: 4.797

5.  Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolism.

Authors:  Weizhi Zhao; Bridget S Mosley; Mario A Cleves; Stepan Melnyk; S Jill James; Charlotte A Hobbs
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2006-04

6.  Reproductive fitness in maternal homocystinuria due to cystathionine beta-synthase deficiency.

Authors:  H L Levy; J E Vargas; S E Waisbren; T W Kurczynski; E R Roeder; R S Schwartz; S Rosengren; C Prasad; C R Greenberg; B M Gilfix; D MacGregor; V E Shih; L Bao; J P Kraus
Journal:  J Inherit Metab Dis       Date:  2002-08       Impact factor: 4.982

7.  Lack of association between folate receptor autoantibodies and conotruncal congenital heart defects.

Authors:  Laura B Lewandowski; Darshak Sanghavi
Journal:  Pediatr Cardiol       Date:  2012-08-23       Impact factor: 1.655

8.  A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population.

Authors:  Jian-Yuan Zhao; Xue-Yan Yang; Kai-Hu Shi; Shu-Na Sun; Jia Hou; Zhi-Zhou Ye; Jue Wang; Wen-Yuan Duan; Bin Qiao; Yi-Jiang Chen; Hong-Bing Shen; Guo-Ying Huang; Li Jin; Hong-Yan Wang
Journal:  Cell Res       Date:  2012-09-18       Impact factor: 25.617

9.  Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.

Authors:  Liyuan Deng; C Lee Elmore; Andrea K Lawrance; Rowena G Matthews; Rima Rozen
Journal:  Mol Genet Metab       Date:  2008-04-14       Impact factor: 4.797

10.  The N-methyl-d-aspartate receptor in heart development: a gene knockdown model using siRNA.

Authors:  Octavian V Lie; Gregory D Bennett; Thomas H Rosenquist
Journal:  Reprod Toxicol       Date:  2009-09-06       Impact factor: 3.143
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