OBJECTIVE: To evaluate the effect of systemic prednisolone as an adjunct to conventional treatment with beta2-agonist, respiratory support, and fluid replacement in hospitalized infants <24 months of age with respiratory syncytial virus (RSV) infection. METHODS: The study was randomized, double-blind, and placebo-controlled. During the winter of 1995-1996, 147 infants <2 years of age, hospitalized with RSV infection, were allocated to treatment with either systemic prednisolone mixture 2 mg/kg daily or placebo for 5 days. MAIN OUTCOME MEASURES: The acute effect variables were duration of stay in hospital, use of medicine, and supportive measures while in hospital. At follow-up 1 month after discharge, the acute effect variables were duration of illness, start in day care center, morbidity, and use of medicine. At follow-up 1 year after discharge, the acute effect variables were morbidity, use of medicine, and skin prick tests with allergens. RESULTS:Prednisolone treatment had no effect on any of the outcome measures. CONCLUSIONS: Our randomized prospective study in infants hospitalized with acute RSV infection showed no effect of systemic prednisolone treatment either in the acute state of RSV infection, nor in the follow-up 1 month and 1 year after admission to hospital. We find our results in agreement with the largest studies reported earlier; therefore, corticosteroid, whether by the systemic route or by inhalation, should not be prescribed to infants with RSV infection.
RCT Entities:
OBJECTIVE: To evaluate the effect of systemic prednisolone as an adjunct to conventional treatment with beta2-agonist, respiratory support, and fluid replacement in hospitalized infants <24 months of age with respiratory syncytial virus (RSV) infection. METHODS: The study was randomized, double-blind, and placebo-controlled. During the winter of 1995-1996, 147 infants <2 years of age, hospitalized with RSV infection, were allocated to treatment with either systemic prednisolone mixture 2 mg/kg daily or placebo for 5 days. MAIN OUTCOME MEASURES: The acute effect variables were duration of stay in hospital, use of medicine, and supportive measures while in hospital. At follow-up 1 month after discharge, the acute effect variables were duration of illness, start in day care center, morbidity, and use of medicine. At follow-up 1 year after discharge, the acute effect variables were morbidity, use of medicine, and skin prick tests with allergens. RESULTS:Prednisolone treatment had no effect on any of the outcome measures. CONCLUSIONS: Our randomized prospective study in infants hospitalized with acute RSV infection showed no effect of systemic prednisolone treatment either in the acute state of RSV infection, nor in the follow-up 1 month and 1 year after admission to hospital. We find our results in agreement with the largest studies reported earlier; therefore, corticosteroid, whether by the systemic route or by inhalation, should not be prescribed to infants with RSV infection.
Authors: Avraham Beigelman; Megan Isaacson-Schmid; Geneline Sajol; Jack Baty; Oscar M Rodriguez; Erin Leege; Kevin Lyons; Toni L Schweiger; Jie Zheng; Kenneth B Schechtman; Mario Castro; Leonard B Bacharier Journal: J Allergy Clin Immunol Date: 2014-11-18 Impact factor: 10.793
Authors: Ricardo M Fernandes; Liza M Bialy; Ben Vandermeer; Lisa Tjosvold; Amy C Plint; Hema Patel; David W Johnson; Terry P Klassen; Lisa Hartling Journal: Cochrane Database Syst Rev Date: 2013-06-04
Authors: Pasi Lehtinen; Aino Ruohola; Timo Vanto; Tytti Vuorinen; Olli Ruuskanen; Tuomas Jartti Journal: J Allergy Clin Immunol Date: 2006-12-27 Impact factor: 10.793
Authors: Mythili Srinivasan; Leonard B Bacharier; Charles W Goss; Yanjiao Zhou; Jonathan Boomer; Sarah Bram; Dana Burgdorf; Carey-Ann Burnham; Timothy Casper; Mario Castro; Andrea Coverstone; Matthew Haslam; Watcharoot Kanchongkittiphon; Cadence Kuklinski; Qinghua Lian; Kenneth Schechtman; Gregory A Storch; Kelly True; Meghan A Wallace; Huiqing Yin-DeClue; Elizabeth Ahrens; Jinli Wang; Avraham Beigelman Journal: Contemp Clin Trials Commun Date: 2021-06-09
Authors: Tuomas Jartti; Pasi Lehtinen; Timo Vanto; Tytti Vuorinen; Jaakko Hartiala; Heikki Hiekkanen; Pekka Malmberg; Mika Mäkelä; Olli Ruuskanen Journal: Pediatr Allergy Immunol Date: 2007-06 Impact factor: 6.377