BACKGROUND: The treatment of deep sternal wound infections remains controversial. Currently advocated procedures carry the risk of reinfections. The significance of local antibiotic-releasing systems as an adjuvant therapy to avoid reinfections is the subject of the presented study. METHODS: Forty-two patients with deep sternal wound complication were treated with radical wound debridement, sternal refixation, retrosternal suction drainage, bilateral pectoralis major muscle flaps, and placement of collagenous drug carrier loaded with gentamycin (Sulmycin Implant) underneath, above, and between the sternal edges. RESULTS: No treatment failure and death were observed in our patients. Side effects after adjuvant treatment with collagenous gentamycin were not detected. CONCLUSIONS: The preliminary results of adjuvant therapy with collagenous gentamycin in combination with surgical debridement leads to excellent results in the treatment of early deep sternal wound infections with no death and no primary treatment failures. This technique is easy to perform, reliable, and safe. For final judgment controlled randomized trials are mandatory.
BACKGROUND: The treatment of deep sternal wound infections remains controversial. Currently advocated procedures carry the risk of reinfections. The significance of local antibiotic-releasing systems as an adjuvant therapy to avoid reinfections is the subject of the presented study. METHODS: Forty-two patients with deep sternal wound complication were treated with radical wound debridement, sternal refixation, retrosternal suction drainage, bilateral pectoralis major muscle flaps, and placement of collagenous drug carrier loaded with gentamycin (Sulmycin Implant) underneath, above, and between the sternal edges. RESULTS: No treatment failure and death were observed in our patients. Side effects after adjuvant treatment with collagenous gentamycin were not detected. CONCLUSIONS: The preliminary results of adjuvant therapy with collagenous gentamycin in combination with surgical debridement leads to excellent results in the treatment of early deep sternal wound infections with no death and no primary treatment failures. This technique is easy to perform, reliable, and safe. For final judgment controlled randomized trials are mandatory.
Authors: Michał Pasierski; Kamil Zieliński; Giuseppe Maria Raffa; Harold Lazar; Roberto Lorusso; Piotr Suwalski; Mariusz Kowalewski Journal: J Thorac Dis Date: 2019-09 Impact factor: 2.895
Authors: Yaron S Brin; Jacob Golenser; Boaz Mizrahi; Guy Maoz; Abraham J Domb; Shyamal Peddada; Shmuel Tuvia; Abraham Nyska; Meir Nyska Journal: J Control Release Date: 2008-07-20 Impact factor: 9.776
Authors: Emilio Bouza; Arístides de Alarcón; María Carmen Fariñas; Juan Gálvez; Miguel Ángel Goenaga; Francisco Gutiérrez-Díez; Javier Hortal; José Lasso; Carlos A Mestres; José M Miró; Enrique Navas; Mercedes Nieto; Antonio Parra; Enrique Pérez de la Sota; Hugo Rodríguez-Abella; Marta Rodríguez-Créixems; Jorge Rodríguez-Roda; Gemma Sánchez Espín; Dolores Sousa; Carlos Velasco García de Sierra; Patricia Muñoz; Martha Kestler Journal: J Clin Med Date: 2021-11-26 Impact factor: 4.241
Authors: M Rizwan Sohail; Zerelda Esquer Garrigos; Claude S Elayi; Kun Xiang; John N Catanzaro Journal: Pacing Clin Electrophysiol Date: 2020-03-05 Impact factor: 1.976