| Literature DB >> 10584206 |
T Y Shin1, H J Jeong, S M Jun, H J Chae, H R Kim, S H Baek, H M Kim.
Abstract
We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-alpha production from RPMC.Entities:
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Year: 1999 PMID： 10584206 DOI： 10.3109/08923979909007136
Source DB: PubMed Journal: Immunopharmacol Immunotoxicol ISSN： 0892-3973 Impact factor: 2.730