Literature DB >> 10584035

Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.

R Zhou1, J E Linz.   

Abstract

The nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus and was predicted to encode a norsolorinic acid ketoreductase. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH. The results confirm that Nor-1 functions as a ketoreductase in vitro.

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Year:  1999        PMID： 10584035      PMCID： PMC91775          DOI： 10.1128/AEM.65.12.5639-5641.1999

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  9 in total

1.  Isolation of averufin from a mutant of Aspergillus parasiticus impaired in aflatoxin biosynthesis.

Authors:  J A Donkersloot; R I Mateles; S S Yang
Journal:  Biochem Biophys Res Commun       Date:  1972-06-09       Impact factor: 3.575

2.  Norsolorinic acid from a mutant strain of Aspergillus parasiticus.

Authors:  L Lee; J W Bennett; L A Goldblatt; R E Lundin
Journal:  J Am Oil Chem Soc       Date:  1971-02       Impact factor: 1.849

Review 3.  Enzymes and aflatoxin biosynthesis.

Authors:  M F Dutton
Journal:  Microbiol Rev       Date:  1988-06

4.  Studies in mycological chemistry. XIX. "Product B" (averantin) [1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)anthraquinone], a pigment from Aspergillus versicolor (Vuillemin) Tiraboschi.

Authors:  J H Birkinshaw; J C Roberts; P Roffey
Journal:  J Chem Soc Perkin 1       Date:  1966

5.  Cloning of a gene associated with aflatoxin B1 biosynthesis in Aspergillus parasiticus.

Authors:  P K Chang; C D Skory; J E Linz
Journal:  Curr Genet       Date:  1992-03       Impact factor: 3.886

6.  Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.

Authors:  F Trail; P K Chang; J Cary; J E Linz
Journal:  Appl Environ Microbiol       Date:  1994-11       Impact factor: 4.792

7.  The affinity purification and characterization of a dehydrogenase from Aspergillus parasiticus involved in aflatoxin B1 biosynthesis.

Authors:  A A Chuturgoon; M F Dutton
Journal:  Prep Biochem       Date:  1991

8.  Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.

Authors:  J W Bennett; L S Lee; S M Shoss; G H Boudreaux
Journal:  Appl Environ Microbiol       Date:  1980-04       Impact factor: 4.792

9.  Enzymatic conversion of norsolorinic acid to averufin in aflatoxin biosynthesis.

Authors:  K Yabe; Y Nakamura; H Nakajima; Y Ando; T Hamasaki
Journal:  Appl Environ Microbiol       Date:  1991-05       Impact factor: 4.792
  9 in total
  15 in total

1.  adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.

Authors:  P K Chang; J Yu; K C Ehrlich; S M Boue; B G Montalbano; D Bhatnagar; T E Cleveland
Journal:  Appl Environ Microbiol       Date:  2000-11       Impact factor: 4.792

2.  Molecular analysis of an inactive aflatoxin biosynthesis gene cluster in Aspergillus oryzae RIB strains.

Authors:  Mihoko Tominaga; Yun-Hae Lee; Risa Hayashi; Yuji Suzuki; Osamu Yamada; Kazutoshi Sakamoto; Kuniyasu Gotoh; Osamu Akita
Journal:  Appl Environ Microbiol       Date:  2006-01       Impact factor: 4.792

3.  Functional expression and sub-cellular localization of the early aflatoxin pathway enzyme Nor-1 in Aspergillus parasiticus.

Authors:  Sung-Yong Hong; John E Linz
Journal:  Mycol Res       Date:  2009-02-13

Review 4.  Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.

Authors:  Bradley S Evans; Sarah J Robinson; Neil L Kelleher
Journal:  Fungal Genet Biol       Date:  2010-06-30       Impact factor: 3.495

5.  Chromosomal location plays a role in regulation of aflatoxin gene expression in Aspergillus parasiticus.

Authors:  Ching-Hsun Chiou; Michael Miller; David L Wilson; Frances Trail; John E Linz
Journal:  Appl Environ Microbiol       Date:  2002-01       Impact factor: 4.792

6.  Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus.

Authors:  Ludmila V Roze; Randolph M Beaudry; Nancy P Keller; John E Linz
Journal:  Mycopathologia       Date:  2004-08       Impact factor: 2.574

7.  Role of cis-acting sites NorL, a TATA box, and AflR1 in nor-1 transcriptional activation in Aspergillus parasiticus.

Authors:  Michael J Miller; Ludmila V Roze; Frances Trail; John E Linz
Journal:  Appl Environ Microbiol       Date:  2005-03       Impact factor: 4.792

8.  Molecular characterization of atoxigenic Aspergillus flavus isolates collected in China.

Authors:  Dandan Wei; Lu Zhou; Jonathan Nimal Selvaraj; Chushu Zhang; Fuguo Xing; Yueju Zhao; Yan Wang; Yang Liu
Journal:  J Microbiol       Date:  2014-05-30       Impact factor: 3.422

9.  Control of aflatoxin production of Aspergillus flavus and Aspergillus parasiticus using RNA silencing technology by targeting aflD (nor-1) gene.

Authors:  Ahmed M Abdel-Hadi; Daniel P Caley; David R F Carter; Naresh Magan
Journal:  Toxins (Basel)       Date:  2011-06-17       Impact factor: 4.546

Review 10.  Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.

Authors:  Jiujiang Yu
Journal:  Toxins (Basel)       Date:  2012-10-25       Impact factor: 4.546
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