| Literature DB >> 10583459 |
O Nathalang1, N Tatsumi, M Hino, W Prayoonwiwat, T Yamane, C Suwanasophon, T Sriphaisal.
Abstract
The distribution of HLA-DRB1 alleles and DQB1 alleles in 100 Thai patients with non-Hodgkin's lymphoma (NHL) was analysed using the polymerase chain reaction with sequence-specific primer (PCR-SSP) method, and the association between the disease and the presence of certain HLA class II alleles was investigated. The frequencies of HLA-DRB1*1502 and DRB1*09012 were increased while those of DRB1*0404, DRB1*0803 and DRB1*1106 were decreased. On the other hand, the incidence of HLA-DQB1 alleles was similar to that in the normal population. Interestingly, only HLA-DRB1*1502 showed a significant positive association with NHL, especially in patients < or / = 45 years and in male patients. It is concluded that the DRB1*1502 allele may contribute to NHL susceptibility in the Thai population. However, further studies on the functional roles of the HLA class II alleles are necessary to elucidate NHL susceptibility.Entities:
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Year: 1999 PMID： 10583459 DOI： 10.1046/j.1365-2370.1999.00177.x
Source DB: PubMed Journal: Eur J Immunogenet ISSN： 0960-7420