Literature DB >> 10582898

Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS.

M K Lacy1, D P Nicolau, C H Nightingale, A Geffken, R Teng, J Vincent, R Quintiliani.   

Abstract

Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

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Year:  1999        PMID： 10582898      PMCID： PMC89603          DOI： 10.1128/AAC.43.12.3005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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Journal:  N Engl J Med       Date:  1992-12-17       Impact factor: 91.245

2.  Pharmacokinetics and safety of oral levofloxacin in human immunodeficiency virus-infected individuals receiving concomitant zidovudine.

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Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Intestinal malabsorption and zidovudine bioavailability.

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Journal:  J Acquir Immune Defic Syndr Hum Retrovirol       Date:  1998-05-01

4.  Kinetics of D-xylose absorption in patients with human immunodeficiency virus enteropathy.

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Journal:  Clin Pharmacol Ther       Date:  1991-06       Impact factor: 6.875

5.  Small intestinal injury and parasitic diseases in AIDS.

Authors:  D P Kotler; A Francisco; F Clayton; J V Scholes; J M Orenstein
Journal:  Ann Intern Med       Date:  1990-09-15       Impact factor: 25.391

6.  Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy.

Authors:  R Ullrich; M Zeitz; W Heise; M L'age; G Höffken; E O Riecken
Journal:  Ann Intern Med       Date:  1989-07-01       Impact factor: 25.391

7.  Erratic zidovudine bioavailability in HIV seropositive patients.

Authors:  K A Macnab; M J Gill; L R Sutherland; N De Boer Visser; D Church
Journal:  J Antimicrob Chemother       Date:  1993-03       Impact factor: 5.790

Review 8.  AIDS enteropathy.

Authors:  J G Bartlett; P C Belitsos; C L Sears
Journal:  Clin Infect Dis       Date:  1992-10       Impact factor: 9.079

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Authors:  P D Smith; T C Quinn; W Strober; E N Janoff; H Masur
Journal:  Ann Intern Med       Date:  1992-01-01       Impact factor: 25.391

10.  Comparative study of bioavailabilities and pharmacokinetics of clindamycin in healthy volunteers and patients with AIDS.

Authors:  G Gatti; J Flaherty; J Bubp; J White; M Borin; J Gambertoglio
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191
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  2 in total

Review 1.  The use of gastrointestinal intubation studies for controlled release development.

Authors:  Steven C Sutton
Journal:  Br J Clin Pharmacol       Date:  2009-09       Impact factor: 4.335

Review 2.  A critical review of the fluoroquinolones: focus on respiratory infections.

Authors:  George G Zhanel; Kelly Ennis; Lavern Vercaigne; Andrew Walkty; Alfred S Gin; John Embil; Heather Smith; Daryl J Hoban
Journal:  Drugs       Date:  2002       Impact factor: 9.546
  2 in total

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