Literature DB >> 10582772

Insulin-like growth factor I: an attractive option for chronic heart failure?

M Y Donath1, J Zapf.   

Abstract

Chronic congestive heart failure is a syndrome with a poor prognosis. Currently, the only therapy providing the possibility of long term survival is heart transplantation. Therefore, new therapeutic strategies continue to be investigated. One such new approach may be the application of recombinant human insulin-like growth factor (IGF)-1. IGF-1 has both acute and long term cardiovascular effects. Acute administration of IGF-1 resulted in a reduction in afterload and positive inotropic effects in patients with heart failure. In vitro and animal studies have demonstrated that IGF-1 can stimulate myofibril formation. In addition, IGF-1 administration has beneficial metabolic effects. The benefits of prolonged IGF-1 therapy have yet to be investigated.

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Year:  1999        PMID： 10582772     DOI： 10.2165/00002512-199915040-00001

Source DB:  PubMed          Journal:  Drugs Aging        ISSN： 1170-229X            Impact factor:   3.923


  47 in total

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Review 4.  The role of the insulin-like growth factor system in neuronal rescue.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

7.  Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.

Authors:  M Y Donath; J Zapf; M Eppenberger-Eberhardt; E R Froesch; H M Eppenberger
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-01       Impact factor: 11.205

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Authors:  M Y Donath; G Sütsch; X W Yan; B Piva; H P Brunner; Y Glatz; J Zapf; F Follath; E R Froesch; W Kiowski
Journal:  J Clin Endocrinol Metab       Date:  1998-09       Impact factor: 5.958

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Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

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Authors:  M A Gosteli-Peter; K H Winterhalter; C Schmid; E R Froesch; J Zapf
Journal:  Endocrinology       Date:  1994-12       Impact factor: 4.736
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  2 in total

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Authors:  Yanzhang Gao; Yongxin Lu; Shaohua Mi; Xiaoming Liu; Guanhua Su; Shuling Rong
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2008-08-15
  2 in total

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