Literature DB >> 10582340

Activation of erythropoietin signaling by receptor dimerization.

S S Watowich1.   

Abstract

The hormone erythropoietin (Epo) is essential for red blood cell development. Epo binds a high affinity receptor on the surface of erythroid progenitor cells, stimulating receptor dimerization and activation of the intracellular signal transduction pathways that support erythroid cell survival, proliferation and differentiation. Biochemical and structural analysis of the erythropoietin receptor (EpoR) is revealing the molecular mechanisms of EpoR function, leading the way to the development of small molecule Epo mimetics. This review focuses on the role EpoR dimerization plays in receptor function.

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Year:  1999        PMID： 10582340     DOI： 10.1016/s1357-2725(99)00075-8

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  10 in total

1.  Evidence for ligand-independent multimerization of the IL-17 receptor.

Authors:  Jill M Kramer; Ling Yi; Fang Shen; Amarnath Maitra; Xuanmao Jiao; Tian Jin; Sarah L Gaffen
Journal:  J Immunol       Date:  2006-01-15       Impact factor: 5.422

2.  Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma.

Authors:  Ahmed Mohyeldin; Huasheng Lu; Clifton Dalgard; Stephen Y Lai; Noam Cohen; Geza Acs; Ajay Verma
Journal:  Neoplasia       Date:  2005-05       Impact factor: 5.715

3.  Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.

Authors:  Haijiao Zhang; Sophie Means; Anna Reister Schultz; Kevin Watanabe-Smith; Bruno C Medeiros; Daniel Bottomly; Beth Wilmot; Shannon K McWeeney; Tim Kükenshöner; Oliver Hantschel; Jeffrey W Tyner
Journal:  Cancer Res       Date:  2017-06-26       Impact factor: 12.701

4.  Tumor necrosis factor α primes cerebral endothelial cells for erythropoietin-induced angiogenesis.

Authors:  Lei Wang; Michael Chopp; Hua Teng; Marianne Bolz; Moniche-Alvarez Francisco; Moniche Ãlvarez Francisco; Danielle Marie Aluigi; Xin Li Wang; Rui Lan Zhang; Søren Chrsitensen; Thomas N Sager; Alexandra Szalad; Zheng Gang Zhang
Journal:  J Cereb Blood Flow Metab       Date:  2010-08-11       Impact factor: 6.200

Review 5.  Discovery and basic pharmacology of erythropoiesis-stimulating agents (ESAs), including the hyperglycosylated ESA, darbepoetin alfa: an update of the rationale and clinical impact.

Authors:  Zoltán Kiss; Steven Elliott; Kinga Jedynasty; Vladimír Tesar; János Szegedi
Journal:  Eur J Clin Pharmacol       Date:  2010-02-02       Impact factor: 2.953

Review 6.  Understanding cytokine and growth factor receptor activation mechanisms.

Authors:  Mariya Atanasova; Adrian Whitty
Journal:  Crit Rev Biochem Mol Biol       Date:  2012-10-09       Impact factor: 8.250

Review 7.  Molecular mechanisms of prolactin and its receptor.

Authors:  Charles L Brooks
Journal:  Endocr Rev       Date:  2012-05-10       Impact factor: 19.871

8.  Natural form of noncytolytic flexible human Fc as a long-acting carrier of agonistic ligand, erythropoietin.

Authors:  Se Jin Im; Sang In Yang; Se Hwan Yang; Dong Hoon Choi; So Young Choi; Hea Sook Kim; Do Soo Jang; Kyeong Sik Jin; Yo-Kyung Chung; Seung-Hee Kim; Sang Hoon Paik; Yoo Chang Park; Moon Koo Chung; Yong Bum Kim; Kang-Hyun Han; Kwan Yong Choi; Young Chul Sung
Journal:  PLoS One       Date:  2011-09-16       Impact factor: 3.240

Review 9.  Progress in detecting cell-surface protein receptors: the erythropoietin receptor example.

Authors:  Steve Elliott; Angus Sinclair; Helen Collins; Linda Rice; Wolfgang Jelkmann
Journal:  Ann Hematol       Date:  2013-12-14       Impact factor: 3.673

10.  The effect of erythropoietin on normal and neoplastic cells.

Authors:  Steve Elliott; Angus M Sinclair
Journal:  Biologics       Date:  2012-06-27
  10 in total

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