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Literature DB >> 1058171

Missing Y chromosome in juvenile chronic myelogenous leukemia.

T Hays, J R Humbert, D C Peakman, J J Hutter, H G Morse, A Robinson, C S August.

Abstract

A child with Ph1-negative juvenile chronic myelogenous leukemia (CML) is presented. The only chromosomal abnormality in hematopoietic tissues consisted of an absent Y chromosome. While a missing Y chromosome in adult patients with CML may be associated with a better prognosis, the clinical course in our patient was as malignant as that usually observed in other children with Ph1-negative juvenile CML.

Entities: Disease Gene Species

Mesh：

Year: 1975 PMID： 1058171 DOI： 10.1007/bf00297633

Source DB: PubMed Journal: Humangenetik ISSN： 0018-7348

15 in total

1. SEX CHROMATIN IN NEWBORNS: PRESUMPTIVE EVIDENCE FOR EXTERNAL FACTORS IN HUMAN NONDISJUNCTON.

Authors: A ROBINSON; T T PUCK
Journal: Science Date: 1965-04-02 Impact factor: 47.728

2. The missing Y chromosome and human leukaemia.

Authors: A A Sandberg; M Sakurai
Journal: Lancet Date: 1973-02-17 Impact factor: 79.321

3. Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging.

Authors: R V Pierre; H C Hoagland
Journal: Cancer Date: 1972-10 Impact factor: 6.860

4. The 45, XO, Ph 1 subgroup of chronic granulocytic leukaemia.

Authors: O M Garson; W J Milligan
Journal: Scand J Haematol Date: 1972

5. [A peculiar form of granulocytic leukemia in the male: prolonged development and the presence of the Philadelphia chromosome, with the loss of Y chromosome in the myeloid cells (apropos of 3 cases)].

Authors: F Bauters; M F Croquette; Y Delmas-Marsalet; M Deminatti; M Goudemand
Journal: Nouv Rev Fr Hematol Date: 1970 Nov-Dec

9. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl.

Authors: D A Hungerford
Journal: Stain Technol Date: 1965-11

Missing Y chromosome in juvenile chronic myelogenous leukemia.

1. SEX CHROMATIN IN NEWBORNS: PRESUMPTIVE EVIDENCE FOR EXTERNAL FACTORS IN HUMAN NONDISJUNCTON.

2. The missing Y chromosome and human leukaemia.

3. Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging.

4. The 45, XO, Ph 1 subgroup of chronic granulocytic leukaemia.

5. [A peculiar form of granulocytic leukemia in the male: prolonged development and the presence of the Philadelphia chromosome, with the loss of Y chromosome in the myeloid cells (apropos of 3 cases)].

Review 6. Chromosomal abnormalities in human neoplasia.

7. Philadelphia-chromosome positive bone-marrow cells showing loss of the Y in males with chronic myeloid leukaemia.

8. Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin.

9. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl.

10. Genetics of somatic mammalian cells. III. Long-term cultivation of euploid cells from human and animal subjects.

1. Familial neurofibromatosis and juvenile chronic myelogenous leukemia.

2. Editorial: Chromosomes and human neoplasms. Achievements using new staining techniques.