Effects of glucose and fructose on recently reactivated and recently acquired memories.

1. The effects of glucose and fructose on memory reactivation were investigated. 2. Rats were trained originally on a brightness discrimination passive avoidance task. 3. Memory reactivation treatment consisted of re-exposing the rats 24 hr later to the footshock unconditioned stimulus in the experimental room. Glucose or fructose (32, 100, 320, 1000, or 2000 mg/kg) was administered immediately after reactivation. 4. Twenty-four hr after reactivation (48 hr after training) the rats were tested for their ability to acquire an active avoidance (reversal) task. 5. The dose-response functions for the effects of both glucose and fructose on the reactivated memory followed identical cubic trends. However, a combined dose of glucose and fructose was significantly less effective at modulating memory than was an equimolar dose of either sugar alone. 6. We compared analytically the effects of combined glucose and fructose treatment on new versus old memories. The dose-response functions for both types of memories follow cubic trends, suggesting that similar multiple interacting mechanisms operate when memories are originally stored and when they are later re-encoded.